{"id":"W2110185508","doi":"10.1128/jvi.05721-11","title":"For Protection from HIV-1 Infection, More Might Not Be Better: a Systematic Analysis of HIV Gag Epitopes of Two Alleles Associated with Different Outcomes of HIV-1 Infection","year":2011,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research Manitoba; University of Manitoba; Canadian Science Centre for Human and Animal Health","funders":"Canadian Institutes of Health Research; Public Health Agency; Public Health Agency of Canada; University of Manitoba; Bill and Melinda Gates Foundation","keywords":"Epitope; ELISPOT; Biology; Human leukocyte antigen; Virology; Antigen; Immunology; Allele; Immune system; CD8; HIV vaccine; Peripheral blood mononuclear cell; Antibody; Genetics; Vaccine trial; Gene; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004481374,0.0002250223,0.0002593031,0.0006150315,0.0002776545,0.0002820768,0.0001404111,0.0002787465,0.0003814601],"category_scores_gemma":[0.0006312143,0.0001408368,0.0002280474,0.0005363784,0.0002241831,0.0001831634,0.0002422709,0.0001411838,0.00008286331],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001118539,"about_ca_system_score_gemma":0.0002044968,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009042283,"about_ca_topic_score_gemma":0.002162023,"domain_scores_codex":[0.9997,0.00007976293,0.000027981,0.0001100121,0.00004804147,0.0000343135],"domain_scores_gemma":[0.9996443,0.00008710025,0.0001238885,0.00004302254,0.00004587371,0.00005571981],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004389827,0.00005099746,0.9620869,0.00008035309,0.0001738319,0.0002846076,0.0002382182,0.00003326116,0.02647938,0.00001976884,0.00006448029,0.01004917],"study_design_scores_gemma":[0.00000782984,0.0003344595,0.9970355,0.00001650214,0.0001172813,0.0009548395,0.0002032606,0.00006272052,0.0008378777,0.00001502507,0.0004113393,0.000003389582],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992993,0.0005134678,0.00006625991,0.000007436617,0.000001220621,0.000005612853,0.00004412578,8.0748e-7,0.00006166339],"genre_scores_gemma":[0.9993851,0.0002283171,0.0001560399,0.00002888499,0.000003789298,0.000006999807,0.0001159428,0.000001311552,0.00007356545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009042283,"threshold_uncertainty_score":0.00237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02946154531281827,"score_gpt":0.2715121937665174,"score_spread":0.2420506484536991,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}