{"id":"W2110239305","doi":"10.1161/jaha.114.000965","title":"Reducing Endoglin Activity Limits Calcineurin and TRPC‐6 Expression and Improves Survival in a Mouse Model of Right Ventricular Pressure Overload","year":2014,"lang":"en","type":"article","venue":"Journal of the American Heart Association","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; Heart and Stroke Foundation; University of Toronto","funders":"National Heart, Lung, and Blood Institute","keywords":"Myofibroblast; TRPC; Calcineurin; Endoglin; Fibrosis; Pressure overload; Medicine; Cardiac fibrosis; Internal medicine; Biology; Receptor; Cell biology; Heart failure; Transplantation; Transient receptor potential channel; Stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006309129,0.00007598046,0.0002411977,0.00003392162,0.00003577678,0.00001117579,0.00007690114,0.00005030717,3.376295e-7],"category_scores_gemma":[0.0008555513,0.00005682519,0.00008102616,0.00005964253,0.00003836244,0.00001061022,0.00005524166,0.000123058,3.566496e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000283866,"about_ca_system_score_gemma":0.00004608888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003991373,"about_ca_topic_score_gemma":0.000004766598,"domain_scores_codex":[0.9990609,0.0003199115,0.0002000623,0.0001158001,0.0001969131,0.0001064321],"domain_scores_gemma":[0.9991474,0.00008214531,0.0005156551,0.0001250426,0.00008062233,0.00004916636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001273137,0.00005938511,0.07933254,0.00001310601,0.00002786142,3.861337e-7,0.00004777328,0.002060706,0.9179178,0.000001060269,0.00009537367,0.0003166897],"study_design_scores_gemma":[0.0005571618,0.0001838717,0.06058609,0.00003782548,0.00004073536,0.000004899432,0.00001840609,0.004623308,0.9337651,0.00004131004,0.00007460461,0.0000666799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992883,0.0002108712,0.0001753383,0.0001745576,0.0000565923,0.00007319137,0.00001223388,0.000001575919,0.00000735289],"genre_scores_gemma":[0.9994109,0.00004965641,0.0003156236,0.00004733191,0.00009459129,0.000001556198,5.561789e-7,0.000008080545,0.00007171167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01874644,"threshold_uncertainty_score":0.2317264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009329855726489526,"score_gpt":0.2480462615559046,"score_spread":0.2387164058294151,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}