{"id":"W2110240718","doi":"10.1080/10715760290021270","title":"Coenzyme Q Cytoprotective Mechanisms for Mitochondrial Complex I Cytopathies Involves NAD(P)H: Quinone Oxidoreductase 1(NQO1)","year":2002,"lang":"en","type":"article","venue":"Free Radical Research","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Toronto","funders":"","keywords":"Cytoprotection; Menadione; Antimycin A; Rotenone; Mitochondrion; NAD+ kinase; Mitochondrial respiratory chain; Biochemistry; Reactive oxygen species; Respiratory chain; Coenzyme Q – cytochrome c reductase; Mitochondrial permeability transition pore; Cytotoxicity; Cytosol; Chemistry; Biology; Cell biology; Programmed cell death; Oxidative stress; Enzyme; Apoptosis; Cytochrome c","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008034742,0.0002788857,0.0003561615,0.0001489003,0.000694178,0.00008476343,0.0007135954,0.0003037438,0.0002423565],"category_scores_gemma":[0.002854017,0.0002518453,0.0002243167,0.0003233585,0.0007456734,0.000008258138,0.0006745607,0.0004493464,0.00006682227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008250517,"about_ca_system_score_gemma":0.00008277396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001915223,"about_ca_topic_score_gemma":0.0002716538,"domain_scores_codex":[0.9967967,0.0002926343,0.0003029738,0.00078929,0.0007718672,0.001046503],"domain_scores_gemma":[0.9981081,0.0002747765,0.00005813731,0.0008242042,0.0003822114,0.0003525148],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004195538,0.0001567394,0.000005636553,0.00004866251,0.00006644226,0.00001622654,0.00009881244,0.000002280203,0.4956222,0.002367328,0.5005329,0.0006631736],"study_design_scores_gemma":[0.00574304,0.00701974,0.0002628602,0.00007430923,0.00004108313,0.00006391163,0.0006887494,0.001684571,0.5672454,0.01221898,0.4041744,0.0007829385],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8354418,0.01968483,0.1032329,0.02134638,0.002939702,0.01157766,0.001951165,0.0002983677,0.003527183],"genre_scores_gemma":[0.9785262,0.0006369685,0.01265761,0.0004046215,0.003708977,0.001276216,0.000222949,0.0001020338,0.002464437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1430844,"threshold_uncertainty_score":0.9999934,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1106897427006343,"score_gpt":0.3482070634875705,"score_spread":0.2375173207869362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}