{"id":"W2110240718","doi":"10.1080/10715760290021270","title":"Coenzyme Q Cytoprotective Mechanisms for Mitochondrial Complex I Cytopathies Involves NAD(P)H: Quinone Oxidoreductase 1(NQO1)","year":2002,"lang":"en","type":"article","venue":"Free Radical Research","topic":"Coenzyme Q10 studies and effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Toronto","funders":"","keywords":"Cytoprotection; Menadione; Antimycin A; Rotenone; Mitochondrion; NAD+ kinase; Mitochondrial respiratory chain; Biochemistry; Reactive oxygen species; Respiratory chain; Coenzyme Q – cytochrome c reductase; Mitochondrial permeability transition pore; Cytotoxicity; Cytosol; Chemistry; Biology; Cell biology; Programmed cell death; Oxidative stress; Enzyme; Apoptosis; Cytochrome c","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003908227,0.0006997071,0.0004282199,0.0002328466,0.0002339437,0.000480498,0.0002418629,0.0004599649,0.001596776],"category_scores_gemma":[0.0002222391,0.0001218091,0.0004238362,0.0001566241,0.0004256891,0.0004381682,0.0002624805,0.0005476525,0.0003263175],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004154668,"about_ca_system_score_gemma":0.000265025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009358004,"about_ca_topic_score_gemma":0.001003578,"domain_scores_codex":[0.9998465,0.00003113152,0.00001779035,0.0000486623,0.0000338377,0.00002215663],"domain_scores_gemma":[0.9997721,0.00004135149,0.00007977676,0.00003646202,0.00004802652,0.00002231376],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001467107,0.00002899782,0.0005736121,0.0002265598,0.00002228622,0.000142334,0.00004484834,0.0001091312,0.9942774,0.0001975281,0.0000805595,0.004150006],"study_design_scores_gemma":[0.00001778547,0.0006613575,0.005938437,0.0000157887,0.00004442791,0.000649899,0.00004254972,0.0003238625,0.9883244,0.0001524899,0.003821711,0.000007380259],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9041465,0.04728142,0.04183353,0.001394466,0.000337429,0.0002616306,0.0006801187,0.0006274338,0.003437442],"genre_scores_gemma":[0.9867089,0.006942813,0.003582911,0.000141985,0.0000333737,0.0000391036,0.0003555729,0.00001137483,0.002184045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001596776,"threshold_uncertainty_score":0.005341768,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1106897427006343,"score_gpt":0.3482070634875705,"score_spread":0.2375173207869362,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}