{"id":"W2110251267","doi":"10.1136/gut.2004.041426","title":"Increased epithelial uptake of protein antigens in the ileum of Crohn’s disease mediated by tumour necrosis factor α","year":2004,"lang":"en","type":"article","venue":"Gut","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; McMaster University; St. Michael's Hospital","funders":"Canadian Institutes of Health Research; Vetenskapsrådet; Crohn's and Colitis Foundation of Canada; Crohn's and Colitis Foundation","keywords":"Horseradish peroxidase; Endosome; Ileum; Tumor necrosis factor alpha; Crohn's disease; Intestinal mucosa; Necrosis; Biology; Antigen; Peroxidase; Pathology; Molecular biology; Chemistry; Internal medicine; Endocrinology; Immunology; Medicine; Intracellular; Biochemistry; Enzyme; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001527679,0.0001422139,0.0001433781,0.00003792702,0.0000307982,0.000007745187,0.0002768234,0.00008704489,0.00003206313],"category_scores_gemma":[0.0002686728,0.0001118344,0.000110804,0.00008483495,0.0001271947,0.000004196001,0.00005150185,0.00006779809,0.000009411759],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001430744,"about_ca_system_score_gemma":0.0002766147,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001901829,"about_ca_topic_score_gemma":0.00009075386,"domain_scores_codex":[0.9989951,0.00007280828,0.0003134827,0.0002124747,0.0001983004,0.0002078968],"domain_scores_gemma":[0.999309,0.000008099718,0.0001381432,0.0003636332,0.00007251752,0.0001086315],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005294984,0.0002262943,0.009396827,0.0000601322,0.00002142824,0.00006931832,0.0001243346,0.00002588899,0.9892643,0.00004881484,0.0001659413,0.00006720181],"study_design_scores_gemma":[0.001187196,0.00005388563,0.760272,0.00003388259,0.00001690955,6.637153e-7,0.00004779354,0.000007388216,0.2375584,0.0001180276,0.0005759014,0.0001279525],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979181,0.0001642731,0.00002710637,0.00008713351,0.00003093128,0.0004701659,0.001213499,0.000006801324,0.00008204647],"genre_scores_gemma":[0.9993982,0.00001923995,0.00006836713,0.0001249246,0.00004514579,0.00005060119,0.0002409127,0.00001741769,0.00003520232],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7517059,"threshold_uncertainty_score":0.4560476,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007145731153270339,"score_gpt":0.2219158259761263,"score_spread":0.214770094822856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}