{"id":"W2110254666","doi":"10.1093/neuonc/noq203","title":"Clinical trial end points for high-grade glioma: the evolving landscape","year":2011,"lang":"en","type":"review","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Clinical trial; Medicine; End point; Clinical study design; Medical physics; Clinical endpoint; Surrogate endpoint; Glioma; Intensive care medicine; Oncology; Internal medicine; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001123689,0.0005630053,0.003509752,0.0002393776,0.0001559088,0.00002865965,0.0004053681,0.0009833343,0.0005049821],"category_scores_gemma":[0.001813785,0.0003111307,0.00155551,0.0002697383,0.0001898583,0.00003519467,0.0001797817,0.0008578242,0.0002407977],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001838373,"about_ca_system_score_gemma":0.0009248781,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002062541,"about_ca_topic_score_gemma":0.00002487752,"domain_scores_codex":[0.9958412,0.0009590022,0.001529764,0.0008648959,0.0002279648,0.0005771667],"domain_scores_gemma":[0.9903427,0.007477799,0.000880514,0.0009054233,0.000117217,0.0002763102],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002058969,0.002379628,0.00005524931,0.001339399,0.0007651515,0.0008010582,0.00003431449,1.216366e-8,0.000005769124,0.0007455851,0.05389769,0.9379172],"study_design_scores_gemma":[0.04160096,0.006864881,0.00004493848,0.0007509504,0.00622714,0.0006258754,0.00000831475,0.000002115023,0.000009150528,0.0001295306,0.9435214,0.0002147691],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000825526,0.9835718,0.000005296808,0.001596324,0.005934971,0.006227185,0.00009224127,0.00008584587,0.0016608],"genre_scores_gemma":[0.0006855222,0.9917318,0.0004301749,0.0008048009,0.003766011,0.00219725,0.0002221124,0.0001248717,0.00003742951],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9377024,"threshold_uncertainty_score":0.9999341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1380726027225687,"score_gpt":0.420979426131299,"score_spread":0.2829068234087303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}