{"id":"W2110254666","doi":"10.1093/neuonc/noq203","title":"Clinical trial end points for high-grade glioma: the evolving landscape","year":2011,"lang":"en","type":"review","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Clinical trial; Medicine; End point; Clinical study design; Medical physics; Clinical endpoint; Surrogate endpoint; Glioma; Intensive care medicine; Oncology; Internal medicine; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008475375,0.001185281,0.003233594,0.003018752,0.0003485041,0.002015383,0.001626451,0.002670824,0.002794999],"category_scores_gemma":[0.0209888,0.0003143385,0.00121924,0.003594393,0.0009936747,0.002450874,0.0006521269,0.003670017,0.001820926],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001807995,"about_ca_system_score_gemma":0.003172787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008968334,"about_ca_topic_score_gemma":0.002085518,"domain_scores_codex":[0.9966305,0.001651389,0.0005816873,0.0002082901,0.0008600126,0.00006807326],"domain_scores_gemma":[0.9770458,0.01787374,0.00183737,0.0002494621,0.002628023,0.0003657607],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002025186,0.00007531375,0.0002920454,0.03017137,0.0002819762,0.0001162543,0.00006872689,0.0004146877,0.000316184,0.004727837,0.05700093,0.9063321],"study_design_scores_gemma":[0.0004179416,0.0004158656,0.002201752,0.06758293,0.0007474922,0.001892208,0.0001900972,0.0005326738,0.0004632998,0.01404197,0.911441,0.00007279472],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00007235485,0.9966211,0.0003903423,0.001799912,0.0004481635,0.00003719989,0.00002518137,0.00001231544,0.0005933775],"genre_scores_gemma":[0.001098676,0.9926179,0.001537108,0.003129487,0.0007728108,0.0001637355,0.00007104264,0.00001249396,0.0005966396],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.008475375,"threshold_uncertainty_score":0.04482263,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1380726027225687,"score_gpt":0.420979426131299,"score_spread":0.2829068234087303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}