{"id":"W2110271023","doi":"10.1074/jbc.m302800200","title":"Genomic Expression Discovery Predicts Pathways and Opposing Functions behind Phenotypes","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health","keywords":"Phenotype; Gene; Biology; Function (biology); Expression (computer science); Computational biology; Gene expression; Functional genomics; Genetics; Genomics; Biological pathway; Regulation of gene expression; Genome; Computer science","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001875661,0.0001296029,0.0001639023,0.00001182849,0.00008527674,0.00004298221,0.0001195137,0.0002040887,0.00002040079],"category_scores_gemma":[0.0001483974,0.00009412278,0.00009631048,0.00002036884,0.00008660806,0.000006709719,0.00007427248,0.0001523404,7.868095e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001853493,"about_ca_system_score_gemma":0.00006784274,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":3.22509e-7,"about_ca_topic_score_gemma":2.163546e-7,"domain_scores_codex":[0.9992716,0.00003473518,0.000283538,0.0001782288,0.00007456559,0.0001573699],"domain_scores_gemma":[0.9994616,0.00001909278,0.0002175849,0.0001349179,0.00005700029,0.0001098346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004758699,0.00005687094,0.006671406,0.00001487459,0.00002667935,0.000005770177,0.00001546092,0.00006768591,0.9926552,0.00001009395,0.0001583163,0.0002700668],"study_design_scores_gemma":[0.0006647923,0.0003193949,0.005375435,0.00003840858,0.00002815501,0.0004089697,0.0003200039,0.0000325096,0.9866788,0.0005005757,0.005424514,0.0002084709],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954536,0.001865599,0.001563425,0.00002240367,0.0001039097,0.00003633233,0.00002671886,0.000002973591,0.0009250363],"genre_scores_gemma":[0.9975179,0.0005505075,0.001425941,0.00004891543,0.0002371526,0.00000143917,0.00003142977,0.000009701373,0.0001770399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005976417,"threshold_uncertainty_score":0.3838215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317491171359272,"score_gpt":0.2092234795250316,"score_spread":0.1960485678114388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}