{"id":"W2110271023","doi":"10.1074/jbc.m302800200","title":"Genomic Expression Discovery Predicts Pathways and Opposing Functions behind Phenotypes","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Cancer Institute; National Institutes of Health","keywords":"Phenotype; Gene; Biology; Function (biology); Expression (computer science); Computational biology; Gene expression; Functional genomics; Genetics; Genomics; Biological pathway; Regulation of gene expression; Genome; Computer science","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001792353,0.0004143857,0.0005387864,0.001086047,0.0003564592,0.001110768,0.000472778,0.0006810472,0.001075253],"category_scores_gemma":[0.007738408,0.0002787258,0.000699013,0.0008776945,0.0008417524,0.0009611144,0.0005144961,0.0006954418,0.0003411508],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006699233,"about_ca_system_score_gemma":0.0004209358,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006082553,"about_ca_topic_score_gemma":0.0004644582,"domain_scores_codex":[0.9989736,0.0002965899,0.00006250128,0.0003367286,0.0002544308,0.00007608658],"domain_scores_gemma":[0.9943365,0.004355138,0.000519993,0.0003664179,0.0003331609,0.00008869107],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002196689,0.0002445519,0.2503127,0.0005344745,0.0003896585,0.001143852,0.0003573989,0.1018619,0.3479477,0.04132885,0.001931406,0.2517509],"study_design_scores_gemma":[0.0001539611,0.0005467561,0.1951492,0.00007192294,0.0004284723,0.002050377,0.0003005099,0.5500553,0.1324251,0.1116517,0.00704253,0.0001242309],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.762346,0.0009981565,0.2301304,0.001359529,0.00005054252,0.00004705396,0.001112058,0.0007325709,0.003223719],"genre_scores_gemma":[0.9549228,0.0002597841,0.04309842,0.0001680217,0.00002774751,0.00003607607,0.001004573,0.00003408026,0.0004485045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001792353,"threshold_uncertainty_score":0.009478986,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01317491171359272,"score_gpt":0.2092234795250316,"score_spread":0.1960485678114388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}