{"id":"W2110311701","doi":"10.1038/msb.2013.9","title":"SH3 interactome conserves general function over specific form","year":2013,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Interactome; Biology; SH3 domain; Saccharomyces cerevisiae; Yeast; Budding yeast; Caenorhabditis elegans; Function (biology); Computational biology; Conserved sequence; Homology (biology); Genetics; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Gene; Peptide sequence; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001638787,0.0002450264,0.0002545237,0.00007088774,0.00007297926,0.00008839602,0.0002359477,0.0003655909,0.0001241783],"category_scores_gemma":[0.00001170924,0.0002110559,0.0001441458,0.0000780006,0.00009768318,0.000009369256,0.0001542792,0.0001353007,0.0002235299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002432368,"about_ca_system_score_gemma":0.00003120229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001779377,"about_ca_topic_score_gemma":0.0000127938,"domain_scores_codex":[0.9986191,0.00009422623,0.0004345924,0.000360842,0.00007591207,0.0004153076],"domain_scores_gemma":[0.9991103,0.00000942836,0.0001647882,0.0004945855,0.0001039616,0.0001169621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005219725,0.00003751072,0.001695625,0.00003732719,0.0001951117,0.000005159478,0.00003690213,0.0001264265,0.9618204,0.008024028,0.02373818,0.004231195],"study_design_scores_gemma":[0.002876988,0.001946652,0.0112121,0.00007869237,0.00007162616,0.0003609057,0.0002664397,0.01127567,0.03575249,0.004680004,0.9297678,0.001710659],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9147279,0.003604229,0.07447661,0.0001079009,0.001650349,0.0005657067,0.0000223198,0.00003170433,0.004813259],"genre_scores_gemma":[0.9967535,0.00008867749,0.000288217,0.0007393716,0.0005147238,0.0001069669,0.0004211701,0.00003139351,0.00105598],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9260678,"threshold_uncertainty_score":0.8606608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006462781367368991,"score_gpt":0.2144220265512477,"score_spread":0.2079592451838787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}