{"id":"W2110311701","doi":"10.1038/msb.2013.9","title":"SH3 interactome conserves general function over specific form","year":2013,"lang":"en","type":"article","venue":"Molecular Systems Biology","topic":"Bioinformatics and Genomic Networks","field":"Biochemistry, Genetics and Molecular Biology","cited_by":71,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Interactome; Biology; SH3 domain; Saccharomyces cerevisiae; Yeast; Budding yeast; Caenorhabditis elegans; Function (biology); Computational biology; Conserved sequence; Homology (biology); Genetics; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Gene; Peptide sequence; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001194653,0.0001853279,0.0002422776,0.0005093478,0.0003569063,0.0004865589,0.0002388808,0.0002354616,0.001441602],"category_scores_gemma":[0.0004613918,0.0001355549,0.0002146107,0.0004972945,0.0003072564,0.0004958339,0.000454317,0.0002289817,0.0003255531],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003667398,"about_ca_system_score_gemma":0.0002720239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001176784,"about_ca_topic_score_gemma":0.002040424,"domain_scores_codex":[0.9998318,0.00001435208,0.000006801669,0.00007025294,0.00004147715,0.00003531876],"domain_scores_gemma":[0.9996732,0.00005825366,0.0000895433,0.00007884164,0.00005178426,0.0000483072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002226109,0.00001887548,0.03370527,0.00009360356,0.00009992491,0.000329716,0.0001451927,0.002615423,0.9434412,0.003365156,0.0002266828,0.01573649],"study_design_scores_gemma":[0.00002895738,0.0002003245,0.7233912,0.0000269603,0.0003282273,0.00375866,0.0003694909,0.03585311,0.2104358,0.009590177,0.01598063,0.00003654236],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923394,0.0001817808,0.003971227,0.00004443144,0.000001722871,0.000004738462,0.00037353,0.0001271471,0.002955926],"genre_scores_gemma":[0.9973327,0.0001203726,0.001028819,0.00002068146,0.000002735868,0.000007258665,0.000638354,0.00002130648,0.0008277609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001441602,"threshold_uncertainty_score":0.004822612,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006462781367368991,"score_gpt":0.2144220265512477,"score_spread":0.2079592451838787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}