{"id":"W2110333540","doi":"10.1073/pnas.0706335105","title":"Biogenesis of extracellular microfibrils: Multimerization of the fibrillin-1 C terminus into bead-like structures enables self-assembly","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Connective tissue disorders research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"Shriners Hospitals for Children - Canada; McGill University","funders":"","keywords":"Fibrillin; Microfibril; Cell biology; Chemistry; Biophysics; Biogenesis; Recombinant DNA; Biochemistry; Biology; Extracellular matrix; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001126864,0.0002677157,0.0001042756,0.0001424131,0.0001609253,0.0002499517,0.0001278056,0.0002171393,0.0005603865],"category_scores_gemma":[0.0001497247,0.0001102956,0.0002066874,0.00006734121,0.0001269725,0.0002284707,0.0001817552,0.0003881588,0.0003445918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002325087,"about_ca_system_score_gemma":0.0001217926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000377103,"about_ca_topic_score_gemma":0.0004359347,"domain_scores_codex":[0.9999186,0.000008514631,0.000004954245,0.00002646656,0.00002211457,0.0000192327],"domain_scores_gemma":[0.9999056,0.0000123427,0.00002902015,0.00001152949,0.00001132635,0.00003019863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001125993,0.000003940751,0.0001122592,0.000009140063,0.000001354644,0.00001616188,0.000005668752,0.00001900088,0.9993671,0.00003719859,0.00001250527,0.0004044895],"study_design_scores_gemma":[0.00000363094,0.00006547298,0.004889523,0.000004173765,0.000009059572,0.0003069019,0.00001227755,0.0009437573,0.9921849,0.00004506515,0.001532049,0.000003113697],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914519,0.001042883,0.006501842,0.00005080843,0.0000143737,0.0000194581,0.0001058017,0.00009501502,0.0007178567],"genre_scores_gemma":[0.9938849,0.0003284043,0.004293412,0.00002134582,0.000007107469,0.00001343806,0.0002198302,0.00001910963,0.001212351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005603865,"threshold_uncertainty_score":0.001874626,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02813201487405663,"score_gpt":0.2968234486973547,"score_spread":0.268691433823298,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}