{"id":"W2110384728","doi":"10.1074/jbc.275.15.11368","title":"Membrane Type 1 Matrix Metalloproteinase-associated Degradation of Tissue Inhibitor of Metalloproteinase 2 in Human Tumor Cell Lines","year":2000,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":101,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; Université de Liège; Fédération Wallonie-Bruxelles","keywords":"Matrix metalloproteinase; HT1080; Transfection; Tissue inhibitor of metalloproteinase; Metalloproteinase; Cell culture; Internalization; Interstitial collagenase; Chemistry; Cell biology; Intracellular; Cell; Endocytosis; Biochemistry; Molecular biology; Collagenase; Biology; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002763531,0.000352859,0.0003424633,0.0003048318,0.0002350233,0.000469776,0.0002863854,0.0003097405,0.003762394],"category_scores_gemma":[0.0002032407,0.0002327439,0.0003073144,0.000497491,0.000172857,0.0002223708,0.0001593287,0.0006879994,0.002188612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003911474,"about_ca_system_score_gemma":0.0002671675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001948575,"about_ca_topic_score_gemma":0.001955644,"domain_scores_codex":[0.9996042,0.00007587099,0.0000417085,0.00008342196,0.0001369814,0.00005784883],"domain_scores_gemma":[0.9998837,0.00002556219,0.00001848879,0.00003274715,0.00002740721,0.00001212016],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001935041,0.00007221574,0.0004019707,0.0001028017,0.00001190647,0.0002229397,0.00006272693,0.0001037648,0.9958317,0.0002212267,0.0004634353,0.002311919],"study_design_scores_gemma":[0.00004632534,0.0004847912,0.005754615,0.00001252745,0.0000391121,0.001432835,0.00005560477,0.001813168,0.9674821,0.00006709187,0.02279901,0.00001271659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9294294,0.01639789,0.03236456,0.0004470142,0.0004024651,0.0004034954,0.007063268,0.0006544165,0.01283741],"genre_scores_gemma":[0.9364499,0.006772256,0.021255,0.0001907452,0.00007182653,0.0005827622,0.01300739,0.00006649941,0.02160353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003762394,"threshold_uncertainty_score":0.01258647,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01362509002774519,"score_gpt":0.2574402272575984,"score_spread":0.2438151372298532,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}