{"id":"W2110388384","doi":"10.1093/infdis/jiq030","title":"Deep Sequencing to Infer HIV-1 Co-Receptor Usage: Application to Three Clinical Trials of Maraviroc in Treatment-Experienced Patients","year":2010,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":151,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; AIDS Vancouver","funders":"Canadian Institutes of Health Research","keywords":"Maraviroc; CCR5 receptor antagonist; V3 loop; Medicine; Placebo; Tropism; Virology; Human immunodeficiency virus (HIV); Clinical trial; Internal medicine; Lentivirus; Tissue tropism; Immunology; Virus; Viral disease; Receptor; Pathology; Chemokine receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01019633,0.0004725082,0.001088738,0.0002944901,0.0005017844,0.0008900393,0.0004883538,0.0007548181,0.0008723605],"category_scores_gemma":[0.008741607,0.0002910713,0.0009942458,0.0002924371,0.0006561042,0.0003540002,0.0007112246,0.001135525,0.0001505809],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009043873,"about_ca_system_score_gemma":0.0009618143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007293914,"about_ca_topic_score_gemma":0.001292529,"domain_scores_codex":[0.996887,0.00221148,0.0001667051,0.0003113847,0.0002459758,0.0001773462],"domain_scores_gemma":[0.9937989,0.00349071,0.000893108,0.0005043313,0.0005196848,0.0007931832],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2051198,0.007395983,0.3081662,0.0009457612,0.004356619,0.0009955382,0.001566142,0.03453478,0.07335167,0.001651907,0.003766974,0.3581487],"study_design_scores_gemma":[0.07659267,0.1724573,0.5957507,0.0003168635,0.003632702,0.002336776,0.0007717431,0.08424706,0.04045755,0.006308896,0.01673941,0.0003883811],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947674,0.001098062,0.002485952,0.0001892217,0.00001651708,0.0002856,0.0003599031,0.00002500271,0.0007722993],"genre_scores_gemma":[0.9940216,0.0001788943,0.004385144,0.0002661733,0.00001324653,0.0003554068,0.0006298603,0.000007254637,0.0001424799],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01019633,"threshold_uncertainty_score":0.05392396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03624897760177231,"score_gpt":0.3813017660857507,"score_spread":0.3450527884839784,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}