{"id":"W2110395460","doi":"10.1093/infdis/jiv037","title":"Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection","year":2015,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"GIS-Institut des Maladies Rares; Canadian Institutes of Health Research; McGill University Health Centre; McGill University; Canadian Foundation for AIDS Research; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Kynurenine; Immunology; Catabolism; Immune system; CD8; Inflammation; Tumor necrosis factor alpha; T cell; Internal medicine; Lipopolysaccharide; Medicine; Biology; Endocrinology; Tryptophan; Metabolism; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002269821,0.0002194167,0.0003192124,0.0002550835,0.0002915115,0.0004518806,0.0001231716,0.000286684,0.0006909134],"category_scores_gemma":[0.0007207041,0.0001353879,0.0001384942,0.0002049567,0.0001574923,0.0002170041,0.000211116,0.0004348813,0.00009937602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002144851,"about_ca_system_score_gemma":0.000151605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004306376,"about_ca_topic_score_gemma":0.00067894,"domain_scores_codex":[0.9998864,0.00003482058,0.000009662432,0.00001990574,0.0000168426,0.00003241107],"domain_scores_gemma":[0.9993554,0.0001192752,0.0003001657,0.00001976325,0.00004523146,0.0001600934],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002085692,0.0001567467,0.9789363,0.00004363014,0.00003652328,0.0008678826,0.0001607289,0.00007610247,0.01024804,0.00001745894,0.00006375814,0.007307217],"study_design_scores_gemma":[0.00001697334,0.0009412942,0.995306,0.00001665769,0.0000323327,0.001984975,0.0001488158,0.0001446121,0.001222319,0.00002449377,0.0001575509,0.000004010397],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993947,0.0004594381,0.00003091359,0.000009845953,0.000001590738,0.000003478181,0.00001991049,0.000001360364,0.00007869986],"genre_scores_gemma":[0.9997453,0.000104662,0.00004607851,0.00001244459,0.000005266551,0.000003251539,0.00003985185,4.009617e-7,0.00004281326],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006909134,"threshold_uncertainty_score":0.002311289,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550695505585165,"score_gpt":0.2477664891037667,"score_spread":0.232259534047915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}