{"id":"W2110395460","doi":"10.1093/infdis/jiv037","title":"Immunosuppressive Tryptophan Catabolism and Gut Mucosal Dysfunction Following Early HIV Infection","year":2015,"lang":"en","type":"article","venue":"The Journal of Infectious Diseases","topic":"Tryptophan and brain disorders","field":"Neuroscience","cited_by":126,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"GIS-Institut des Maladies Rares; Canadian Institutes of Health Research; McGill University Health Centre; McGill University; Canadian Foundation for AIDS Research; Styrelsen för Internationellt Utvecklingssamarbete","keywords":"Kynurenine; Immunology; Catabolism; Immune system; CD8; Inflammation; Tumor necrosis factor alpha; T cell; Internal medicine; Lipopolysaccharide; Medicine; Biology; Endocrinology; Tryptophan; Metabolism; Amino acid; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002472463,0.0001699011,0.0002141424,0.000175835,0.0002817559,0.0001253741,0.0001632635,0.00005405346,0.00001713688],"category_scores_gemma":[0.001231308,0.0001151991,0.000152229,0.0002779088,0.0001445132,0.0007070332,0.00006733331,0.0002503231,0.00002364679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006395127,"about_ca_system_score_gemma":0.0001203586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001064145,"about_ca_topic_score_gemma":0.00001055496,"domain_scores_codex":[0.9986007,0.0003483161,0.0003045231,0.0001412299,0.0003836814,0.0002215373],"domain_scores_gemma":[0.9988784,0.0002856278,0.0003350287,0.0001757086,0.0001090516,0.0002162393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003990714,0.002563856,0.4878868,0.0001652303,0.0005623642,0.00042062,0.01621328,0.004113616,0.4124698,0.002612403,0.02828318,0.04071817],"study_design_scores_gemma":[0.01304051,0.002034121,0.9166561,0.0002139004,0.0006810736,0.001941483,0.001337501,0.0003771953,0.04069534,0.0180104,0.004205414,0.0008069978],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957633,0.001166744,0.0005931972,0.0002069339,0.001350746,0.0001481437,0.000009168856,0.00006695963,0.0006948129],"genre_scores_gemma":[0.9989569,0.0003060223,0.000006505017,0.0002910046,0.0003351981,0.000004281733,0.000001070719,0.00002085893,0.00007812047],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4287693,"threshold_uncertainty_score":0.4697684,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01550695505585165,"score_gpt":0.2477664891037667,"score_spread":0.232259534047915,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}