{"id":"W2110438110","doi":"10.1093/toxsci/kfr109","title":"A Safety Evaluation of DAS181, a Sialidase Fusion Protein, in Rodents","year":2011,"lang":"en","type":"article","venue":"Toxicological Sciences","topic":"Inhalation and Respiratory Drug Delivery","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Anthropology Society","funders":"National Institute of Allergy and Infectious Diseases; U.S. Public Health Service; National Institutes of Health; U.S. Department of Health and Human Services","keywords":"Inhalation; Toxicity; Alkaline phosphatase; Beagle; Physiology; Medicine; Respiratory system; Pathology; Respiratory tract; Inhalation exposure; Internal medicine; Pharmacology; Immunology; Andrology; Endocrinology; Biology; Biochemistry; Anesthesia; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002220648,0.00005808682,0.0001401208,0.00009975892,0.00006715833,0.000004990536,0.00009118501,0.00007913282,0.002154897],"category_scores_gemma":[0.0004209714,0.00003469856,0.00003616409,0.0003997442,0.0002665613,0.00007609446,0.00003963538,0.00007375675,0.00002758779],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005280485,"about_ca_system_score_gemma":0.0001869339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002093632,"about_ca_topic_score_gemma":0.00002058091,"domain_scores_codex":[0.998638,0.0001935061,0.0002470912,0.0001842699,0.0005999823,0.0001371331],"domain_scores_gemma":[0.9996393,0.00002340289,0.00008236096,0.00007956944,0.0001152275,0.00006011007],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00161499,0.004503699,0.1612184,0.00009714675,0.0000229111,0.00009356743,0.003602613,0.0002832737,0.6569054,0.008517271,0.0001752687,0.1629654],"study_design_scores_gemma":[0.003874917,0.002646012,0.8450353,0.000231328,0.00006081762,0.00001614005,0.0008789744,0.01244471,0.1325042,0.00160696,0.0004752475,0.0002253554],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9605167,0.00004941701,0.00001727422,0.0001380804,0.00005153569,0.0005789298,8.132318e-7,0.00001518879,0.03863205],"genre_scores_gemma":[0.9991133,0.000003653397,0.000511452,0.0002218185,0.00002014657,0.00001774218,9.204533e-7,0.000001373864,0.0001095498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6838169,"threshold_uncertainty_score":0.9987572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.199580531020135,"score_gpt":0.368286682770705,"score_spread":0.1687061517505699,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}