{"id":"W2110447934","doi":"10.4049/jimmunol.172.1.79","title":"Rosmarinic Acid Induces p56 <i>lck</i> -Dependent Apoptosis in Jurkat and Peripheral T Cells via Mitochondrial Pathway Independent from Fas/Fas Ligand Interaction","year":2004,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":68,"is_retracted":false,"has_abstract":true,"ca_institutions":"Biotechnology Research Institute","funders":"","keywords":"Jurkat cells; Apoptosis; Cell biology; Intrinsic apoptosis; Caspase; Biology; Fas receptor; Caspase 8; Inhibitor of apoptosis domain; Fas ligand; Cytochrome c; Mitochondrion; Cytotoxic T cell; T cell; Immune system; Programmed cell death; Biochemistry; Immunology; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007225275,0.0002651347,0.00020125,0.0001360177,0.0001367382,0.0002242703,0.0001023074,0.0001634681,0.00166676],"category_scores_gemma":[0.00007419593,0.00008494475,0.000229778,0.0001431613,0.0001169545,0.0001401376,0.0001219068,0.0006035805,0.0005720755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002028173,"about_ca_system_score_gemma":0.000160627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002829762,"about_ca_topic_score_gemma":0.0004638906,"domain_scores_codex":[0.9998951,0.00001678841,0.00001126578,0.00001936133,0.00002111987,0.00003635844],"domain_scores_gemma":[0.9999248,0.000009393291,0.0000244226,0.0000139013,0.00001062419,0.00001687154],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001928626,0.00003333364,0.0001074549,0.00003279967,0.000003610519,0.00003453852,0.000009965845,0.00001773144,0.9987755,0.00003360007,0.00003415909,0.0007243659],"study_design_scores_gemma":[0.00004591262,0.0004736847,0.00387006,0.000006630281,0.00001729072,0.0002595668,0.00002470019,0.0003205892,0.9928703,0.00005744176,0.002050379,0.000003383427],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923189,0.002145309,0.002126399,0.0001155981,0.00005077305,0.00005238456,0.0005055816,0.0001029501,0.002581987],"genre_scores_gemma":[0.9938816,0.001084553,0.001199897,0.0001215204,0.00002597832,0.00005129038,0.0008410997,0.00001907373,0.002775045],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00166676,"threshold_uncertainty_score":0.005575836,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00683841257427505,"score_gpt":0.2140766529717202,"score_spread":0.2072382403974451,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}