{"id":"W2110466050","doi":"10.1371/journal.pone.0052463","title":"Recovery of Red Fluorescent Protein Chromophore Maturation Deficiency through Rational Design","year":2012,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Advanced Fluorescence Microscopy Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Defense Advanced Research Projects Agency; Advanced Research Projects Agency; National Institutes of Health; University of Ottawa; California Institute of Technology; Gordon and Betty Moore Foundation; U.S. Department of Energy","keywords":"Chromophore; Fluorescence; Rational design; Biophysics; Chemistry; Biology; Photochemistry; Genetics; Optics; Physics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005946219,0.0006257539,0.0006845646,0.0003895372,0.0002611383,0.0008117766,0.0006293335,0.0004427875,0.0004987051],"category_scores_gemma":[0.0005181874,0.0004099778,0.0005320006,0.0003606514,0.0005271545,0.0003928845,0.0003959377,0.001060881,0.0003343436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008056574,"about_ca_system_score_gemma":0.0008178097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006475948,"about_ca_topic_score_gemma":0.001073258,"domain_scores_codex":[0.9996574,0.00005781595,0.00005135969,0.0000640308,0.00009804474,0.00007134546],"domain_scores_gemma":[0.9997312,0.00004269812,0.0001068378,0.0000321006,0.00004494724,0.00004221766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002122123,0.0002832396,0.0003758145,0.0001516358,0.00003961751,0.0003784537,0.00007100614,0.009416631,0.9765479,0.002310527,0.0001321174,0.01008094],"study_design_scores_gemma":[0.00009071118,0.0006444657,0.0005468331,0.00002140648,0.00007044646,0.0003439501,0.00005606105,0.01474308,0.9756517,0.0003629737,0.007437739,0.00003049644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9262344,0.00146985,0.06774394,0.0003747423,0.00006353523,0.0005284945,0.0003524604,0.0003752193,0.002857337],"genre_scores_gemma":[0.9209031,0.002726958,0.07348534,0.00009920889,0.00001359715,0.0002474338,0.0005630202,0.0001182188,0.001842957],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008117766,"threshold_uncertainty_score":0.005845487,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03656646779774955,"score_gpt":0.2600207074791119,"score_spread":0.2234542396813623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}