{"id":"W2110477438","doi":"10.1089/aid.2014.0361","title":"Mutations in CypA Binding Region of HIV-1 Capsid Affect Capsid Stability and Viral Replication in Primary Macrophages","year":2015,"lang":"en","type":"article","venue":"AIDS Research and Human Retroviruses","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Landsteiner Foundation for Blood Transfusion Research","keywords":"Cypa; Capsid; Cyclophilin A; Biology; Mutant; Viral replication; Infectivity; Virology; Host factor; Virus; Cis-trans-Isomerases; Wild type; Molecular biology; Gene; Peptidylprolyl isomerase; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001650557,0.0001233834,0.0002801418,0.0006440977,0.0001814799,0.00003288383,0.0001362149,0.0001302789,0.00004466474],"category_scores_gemma":[0.000551281,0.0001073984,0.00002593834,0.0003313703,0.0008938779,0.0001953342,0.0001659001,0.0004412896,0.00004743045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002471291,"about_ca_system_score_gemma":0.000172638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002452452,"about_ca_topic_score_gemma":0.001131495,"domain_scores_codex":[0.9978636,0.0007542566,0.0002934245,0.0004497405,0.0001352995,0.000503673],"domain_scores_gemma":[0.9989455,0.0003789216,0.00005625951,0.0003923676,0.000138416,0.00008853361],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003671947,0.0003210061,0.8602281,0.00008977677,0.00003315826,0.00004853847,0.001212577,3.726873e-7,0.1342592,0.000745724,0.0005576896,0.002136725],"study_design_scores_gemma":[0.003345484,0.002726536,0.9140817,0.00008313994,0.000007863043,0.00003057176,0.001386685,6.127543e-7,0.07626331,0.001534333,0.0004044141,0.0001353387],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957937,0.002396773,0.000003999788,0.00009996111,0.00001714651,0.0005359073,0.00008492385,0.00001619661,0.001051363],"genre_scores_gemma":[0.9987457,0.0002532149,0.00004992422,0.000007058045,0.00001022714,0.0000921239,0.0002557243,0.00001107549,0.0005748888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05799586,"threshold_uncertainty_score":0.4379581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1010021453316661,"score_gpt":0.3683410618191291,"score_spread":0.267338916487463,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}