{"id":"W2110485432","doi":"10.1093/hmg/ddi023","title":"Mutant carbonic anhydrase 4 impairs pH regulation and causes retinal photoreceptor degeneration","year":2004,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":90,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Center for Research Resources; National Eye Institute","keywords":"Biology; Carbonic anhydrase; Retinal degeneration; Mutant; Retinal; Retina; Degeneration (medical); Cell biology; Biochemistry; Carbonic anhydrase II; Enzyme; Gene; Neuroscience","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001090661,0.0002214916,0.0001302317,0.00006361274,0.0001639025,0.00005881295,0.0001093194,0.0001545449,0.00002256986],"category_scores_gemma":[0.00002688815,0.0002369044,0.0000662627,0.00008656872,0.0001185905,0.000004607524,0.00007994739,0.0000716917,0.000006394467],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000330121,"about_ca_system_score_gemma":0.0001040644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002595631,"about_ca_topic_score_gemma":0.00008758541,"domain_scores_codex":[0.9988225,0.00004898485,0.0002443102,0.0004186454,0.0002008443,0.0002647061],"domain_scores_gemma":[0.9994249,0.000002418339,0.00008949953,0.0002830493,0.00008295041,0.0001171253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003269406,0.00003719594,0.002131119,0.00001427559,0.00002677982,0.000009882939,0.00009325336,0.0008804563,0.9960574,0.0003517425,0.00008633994,0.000278842],"study_design_scores_gemma":[0.001002476,0.0003818415,0.02226241,0.00001890098,0.00004165769,0.0000287338,0.0000625721,0.00007119583,0.972882,0.001164325,0.001716694,0.0003671458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948637,0.001662219,0.002525903,0.00007440078,0.00008095819,0.0002631545,0.000005457828,0.00002190632,0.0005022577],"genre_scores_gemma":[0.9968506,0.0002932737,0.00207741,0.0002047533,0.0001071373,0.00002235067,0.0003197299,0.0000395584,0.00008526022],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02317537,"threshold_uncertainty_score":0.9660682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007373646681315872,"score_gpt":0.2339371573725941,"score_spread":0.2265635106912782,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}