{"id":"W2110500811","doi":"10.1111/j.1365-2958.2009.06915.x","title":"Cytochrome P450 125 (CYP125) catalyses C26‐hydroxylation to initiate sterol side‐chain degradation in <i>Rhodococcus jostii</i> RHA1","year":2009,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Rijksuniversiteit Groningen; Michael Smith Health Research BC","keywords":"Sterol; Rhodococcus; Biology; Side chain; Hydroxylation; Biochemistry; Steroid; Cholesterol; Cytochrome; Cholestanol; Monooxygenase; Mutant; Microbiology; Cytochrome P450; Stereochemistry; Gene; Chemistry; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002340728,0.0004066547,0.0003702976,0.0001223681,0.00007611672,0.00004050792,0.0004235098,0.0005381367,0.00002097592],"category_scores_gemma":[0.0001533915,0.0004460966,0.0001551281,0.0002811403,0.00007867339,0.0000104147,0.0001637035,0.000230266,0.00004834115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007288595,"about_ca_system_score_gemma":0.00008328439,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002751969,"about_ca_topic_score_gemma":0.00003878641,"domain_scores_codex":[0.9977279,0.0001454001,0.000533901,0.0008916603,0.00009108861,0.0006100329],"domain_scores_gemma":[0.9988985,0.00002000773,0.000165401,0.0006552194,0.0001022269,0.0001586205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002355426,0.0001167294,0.0001893617,0.0000232524,0.00004080961,0.00006126185,0.00004162059,0.0002574524,0.997159,0.00001047402,0.0004693911,0.0013951],"study_design_scores_gemma":[0.0009966106,0.0004697423,0.001288623,0.00004325267,0.00002747989,0.0001847324,0.00002545854,0.0000141309,0.9918759,0.0001061139,0.004472123,0.0004957681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924328,0.0006988177,0.004874991,0.0005206864,0.00008357427,0.0004138626,0.0000996084,0.00003980021,0.0008358673],"genre_scores_gemma":[0.9930654,0.00003516771,0.0006747243,0.003288419,0.0001522078,0.00004386708,0.00243191,0.00003295149,0.0002753352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00528304,"threshold_uncertainty_score":0.9997991,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007610517198452538,"score_gpt":0.2483082737475555,"score_spread":0.2406977565491029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}