{"id":"W2110500811","doi":"10.1111/j.1365-2958.2009.06915.x","title":"Cytochrome P450 125 (CYP125) catalyses C26‐hydroxylation to initiate sterol side‐chain degradation in <i>Rhodococcus jostii</i> RHA1","year":2009,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":131,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Rijksuniversiteit Groningen; Michael Smith Health Research BC","keywords":"Sterol; Rhodococcus; Biology; Side chain; Hydroxylation; Biochemistry; Steroid; Cholesterol; Cytochrome; Cholestanol; Monooxygenase; Mutant; Microbiology; Cytochrome P450; Stereochemistry; Gene; Chemistry; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001077125,0.0003376279,0.0002454561,0.0001297392,0.0001407852,0.0002399331,0.000137048,0.0001649696,0.0004604195],"category_scores_gemma":[0.0001589545,0.0001164237,0.0002909753,0.0001246132,0.0001887105,0.00009604672,0.0001377282,0.0003189991,0.0004529601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003786957,"about_ca_system_score_gemma":0.000188595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003755876,"about_ca_topic_score_gemma":0.002276607,"domain_scores_codex":[0.9998735,0.0000221534,0.0000112138,0.00003371184,0.00003699323,0.00002241078],"domain_scores_gemma":[0.9998839,0.00001610285,0.00004079331,0.00001448462,0.00002476347,0.00001992473],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003100933,0.000007933472,0.0005205408,0.00001503551,0.000004035874,0.00004559781,0.000008650843,0.00003409631,0.9984719,0.00003268417,0.00003511663,0.0007932538],"study_design_scores_gemma":[0.000007014653,0.00007853594,0.01164817,0.000002734015,0.00001166859,0.0005013529,0.0000263074,0.0008917265,0.9854064,0.00003389079,0.001386736,0.000005463106],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994216,0.0007012812,0.003071303,0.00008971582,0.0000176253,0.00002520094,0.000335559,0.0001094771,0.0014338],"genre_scores_gemma":[0.9958559,0.0002467563,0.001964503,0.00002765043,0.000004801068,0.000009228636,0.0004873682,0.00002283872,0.001381069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003755876,"threshold_uncertainty_score":0.007467985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007610517198452538,"score_gpt":0.2483082737475555,"score_spread":0.2406977565491029,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}