{"id":"W2110508299","doi":"10.1002/jmri.24550","title":"White matter lesion load is associated with resting state functional MRI activity and amyloid pet but not FDG in mild cognitive impairment and early alzheimer's disease patients","year":2013,"lang":"en","type":"article","venue":"Journal of Magnetic Resonance Imaging","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; Alzheimer's Association; Amorfix Life Sciences; F. Hoffmann-La Roche; Medpace; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Synarc; Bayer HealthCare; Meso Scale Diagnostics; Foundation for the National Institutes of Health","keywords":"Positron emission tomography; Medicine; Neuroimaging; White matter; Resting state fMRI; Standardized uptake value; Alzheimer's Disease Neuroimaging Initiative; Default mode network; Magnetic resonance imaging; Alzheimer's disease; Amyloid (mycology); Nuclear medicine; Fluid-attenuated inversion recovery; Lesion; Hyperintensity; Pathology; Neuroscience; Internal medicine; Disease; Psychology; Functional magnetic resonance imaging; Radiology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002832589,0.0004554401,0.0004511248,0.0009404151,0.0003405091,0.0005326348,0.0002310187,0.0005663267,0.001113155],"category_scores_gemma":[0.001672623,0.000234985,0.0002420675,0.0004703148,0.0002808207,0.0003248989,0.0002801169,0.0002681807,0.0002191596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000197646,"about_ca_system_score_gemma":0.0001179946,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001880795,"about_ca_topic_score_gemma":0.002638056,"domain_scores_codex":[0.9998468,0.00002762275,0.00002836148,0.00004379594,0.00003042919,0.0000229683],"domain_scores_gemma":[0.9991384,0.0001601086,0.0004152057,0.00004288798,0.00006858553,0.0001747665],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008304112,0.0001148233,0.9929063,0.00001698665,0.0001348727,0.0004652859,0.0001641999,0.00006107126,0.002914886,0.00001577242,0.00005740946,0.002317962],"study_design_scores_gemma":[0.000007542127,0.0000888248,0.9992093,0.000001581928,0.00001766419,0.0004369036,0.000037004,0.00008030854,0.00007797263,0.00002183072,0.00001916731,0.000001860464],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9997639,0.00007194987,0.00002117957,0.000008665937,0.000001082894,0.000002435563,0.00003410028,0.000001733604,0.00009501279],"genre_scores_gemma":[0.9997379,0.00002867929,0.00003670983,0.00001184487,0.00000619157,0.000004367878,0.0001110527,9.421476e-7,0.00006223362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001880795,"threshold_uncertainty_score":0.003739774,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01992314505988498,"score_gpt":0.2373373987313358,"score_spread":0.2174142536714508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}