{"id":"W2110508299","doi":"10.1002/jmri.24550","title":"White matter lesion load is associated with resting state functional MRI activity and amyloid pet but not FDG in mild cognitive impairment and early alzheimer's disease patients","year":2013,"lang":"en","type":"article","venue":"Journal of Magnetic Resonance Imaging","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute on Aging; National Institutes of Health; Genentech; National Institute of Neurological Disorders and Stroke; IXICO; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; University of California, Los Angeles; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; Alzheimer's Association; Amorfix Life Sciences; F. Hoffmann-La Roche; Medpace; AstraZeneca; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Synarc; Bayer HealthCare; Meso Scale Diagnostics; Foundation for the National Institutes of Health","keywords":"Positron emission tomography; Medicine; Neuroimaging; White matter; Resting state fMRI; Standardized uptake value; Alzheimer's Disease Neuroimaging Initiative; Default mode network; Magnetic resonance imaging; Alzheimer's disease; Amyloid (mycology); Nuclear medicine; Fluid-attenuated inversion recovery; Lesion; Hyperintensity; Pathology; Neuroscience; Internal medicine; Disease; Psychology; Functional magnetic resonance imaging; Radiology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000384376,0.0002295151,0.0002891917,0.0001725101,0.0002218143,0.0001682822,0.00008121184,0.00001649036,0.00006816001],"category_scores_gemma":[0.00133838,0.000189798,0.00004471287,0.0002104323,0.0002625374,0.0009288568,0.000133539,0.000351217,0.000009179896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001295354,"about_ca_system_score_gemma":0.00009431722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001296522,"about_ca_topic_score_gemma":0.00002114133,"domain_scores_codex":[0.9978631,0.0002289185,0.0003548501,0.0004291042,0.0007796981,0.0003444024],"domain_scores_gemma":[0.9973174,0.001669079,0.0004126438,0.00009429214,0.0003399661,0.0001666697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0009547857,0.0001828497,0.9894379,0.00001343148,0.0000108195,0.0001152487,0.0004177665,0.00002996303,0.001797428,4.030407e-7,0.001076231,0.005963222],"study_design_scores_gemma":[0.002678034,0.0003529311,0.9938679,0.0005169517,0.00004752483,0.00006122329,0.00008185954,0.00134169,0.0007211179,0.00009445148,0.00002679927,0.0002095449],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932196,0.001130348,0.00002853259,0.005017014,0.0001105904,0.0003733947,0.00004066606,0.000009919351,0.00006996089],"genre_scores_gemma":[0.9976475,0.0001091302,0.0001082426,0.001912992,0.000037021,0.00002188952,4.216093e-7,0.00002106511,0.0001417245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005753676,"threshold_uncertainty_score":0.7739738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01992314505988498,"score_gpt":0.2373373987313358,"score_spread":0.2174142536714508,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}