{"id":"W2110535287","doi":"10.1210/me.2014-1084","title":"Minireview: Pioneer Transcription Factors in Cell Fate Specification","year":2014,"lang":"en","type":"review","venue":"Molecular Endocrinology","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":52,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research","keywords":"Biology; Epigenome; Transcription factor; Chromatin; Cell fate determination; Cellular differentiation; Computational biology; Chromatin remodeling; Epigenetics; Cell biology; Gene; Bioinformatics; Genetics; Gene expression; DNA methylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001248484,0.0005613265,0.001198101,0.0002312278,0.00004044849,0.00002575696,0.0005062218,0.0005543167,0.00002700712],"category_scores_gemma":[0.0000338126,0.0005337229,0.000569765,0.0001701948,0.00007429282,0.00000244095,0.0001153202,0.0003405242,0.00008506787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000747755,"about_ca_system_score_gemma":0.0001069312,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001330346,"about_ca_topic_score_gemma":0.00002612561,"domain_scores_codex":[0.9973482,0.0003440827,0.000817349,0.0008165165,0.000122934,0.000550936],"domain_scores_gemma":[0.9986672,0.00001724457,0.000354123,0.0008306535,0.00004528902,0.00008545294],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002870545,0.0005869996,0.000114117,0.02115644,0.0004459132,0.0001724293,0.0001200221,0.0001699307,0.1172406,0.002463495,0.00154422,0.8559572],"study_design_scores_gemma":[0.0002909859,0.0001167309,0.00002004707,0.0003656491,0.0001843578,0.00004954972,0.00001092283,0.00001147971,0.003088376,0.00003986729,0.995323,0.0004990126],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.006135369,0.9894129,0.002392364,0.00002431732,0.0003638144,0.0007077543,0.00004241206,0.00001892588,0.0009021431],"genre_scores_gemma":[0.006839177,0.9899111,0.0003488535,0.00006645679,0.0001006024,0.0001385542,0.002107166,0.0001093084,0.0003788143],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9937788,"threshold_uncertainty_score":0.9997115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01988131343161002,"score_gpt":0.2699938367518213,"score_spread":0.2501125233202112,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}