{"id":"W2110546638","doi":"10.1111/j.1365-2559.2008.03161.x","title":"Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype","year":2008,"lang":"en","type":"article","venue":"Histopathology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; National Institutes of Health; Gary Bennett Family Fund; National Cancer Institute; Entertainment Industry Foundation","keywords":"Cyclin D1; Microsatellite instability; MLH1; Cancer research; Biology; Colorectal cancer; DNA methylation; CDKN2A; Cancer; Cell cycle; DNA mismatch repair; Genetics; Gene; Gene expression; Microsatellite","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002136524,0.0001684259,0.0002923721,0.0001011375,0.00005823202,0.000003927152,0.000166525,0.0002911094,0.0001217327],"category_scores_gemma":[0.00005200795,0.0001776798,0.00008192418,0.0001225075,0.0001718579,0.000004689985,0.00007738479,0.0001331609,0.000007851839],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005154874,"about_ca_system_score_gemma":0.0001602526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004994231,"about_ca_topic_score_gemma":0.000680421,"domain_scores_codex":[0.9986728,0.0001263569,0.000386173,0.000411456,0.0001267914,0.0002763681],"domain_scores_gemma":[0.9993622,0.0000199898,0.0001873911,0.0002728613,0.00009745182,0.00006009212],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001290784,0.00009037675,0.1167674,0.00001819762,0.000006190312,0.0000171805,0.0003531578,0.0001136815,0.8818783,0.00003551596,0.0003135473,0.00027741],"study_design_scores_gemma":[0.0008957405,0.0002335348,0.1661167,0.000009993101,0.00001247626,0.0000116035,0.0000151636,0.00002862293,0.8161979,0.0002762765,0.0160165,0.0001854762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986399,0.01103586,0.0007052579,0.00004238841,0.0004069023,0.0001693649,0.0001084378,0.000006631551,0.001126178],"genre_scores_gemma":[0.9952525,0.002934929,0.0007574316,0.0001161515,0.00008967541,0.00003894728,0.00008714726,0.00002467973,0.0006984877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06568037,"threshold_uncertainty_score":0.7245574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01384403799254265,"score_gpt":0.255867153557123,"score_spread":0.2420231155645803,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}