{"id":"W2110582364","doi":"10.1183/13993003/erj.42.suppl_57.p657","title":"PBI-compound, a novel first-in-class anti-inflammatory/fibrotic compound, reduces bleomycin-induced pulmonary fibrosis by regulating inflammatory cytokines in bronchoalveolar fluid","year":2013,"lang":"en","type":"article","venue":"European Respiratory Journal","topic":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aptose Biosciences (Canada)","funders":"","keywords":"Bleomycin; Medicine; Bronchoalveolar lavage; CTGF; Pulmonary fibrosis; Fibrosis; Lung; Pathogenesis; Cytokine; Pathology; Proinflammatory cytokine; Inflammation; Tumor necrosis factor alpha; Masson's trichrome stain; Immunology; Internal medicine; Growth factor; Chemotherapy; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000695676,0.0004520667,0.0003992433,0.0004629311,0.0001610882,0.0001620863,0.000254304,0.0002369012,0.00255475],"category_scores_gemma":[0.00005482624,0.0001117948,0.0002388068,0.0001838336,0.0002196836,0.0001799379,0.0001377228,0.0007398405,0.0006494862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001833029,"about_ca_system_score_gemma":0.0003139614,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003372301,"about_ca_topic_score_gemma":0.0006875021,"domain_scores_codex":[0.9999639,0.000003824689,0.000002413403,0.000007415846,0.00001116931,0.00001132874],"domain_scores_gemma":[0.9999552,0.000003670826,0.00001288783,0.000002429375,0.000007944447,0.00001780814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008965049,0.0004550039,0.0004377501,0.0006672785,0.00003659854,0.0002765172,0.00001926273,0.0004073742,0.9736075,0.0002787056,0.0008328185,0.02208473],"study_design_scores_gemma":[0.0006795358,0.008210419,0.007704204,0.00007833278,0.0001250003,0.001976633,0.00002625166,0.001095905,0.9564403,0.0001430938,0.02349062,0.00002972009],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9237756,0.04723694,0.0106644,0.0008679544,0.0003782083,0.0004510392,0.002428915,0.0008986006,0.0132984],"genre_scores_gemma":[0.9588935,0.02274426,0.007944886,0.0003867088,0.0001130451,0.0002030258,0.002353922,0.0000500584,0.007310615],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00255475,"threshold_uncertainty_score":0.008546472,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01547873230099095,"score_gpt":0.2356086723435832,"score_spread":0.2201299400425922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}