{"id":"W2110623818","doi":"10.1161/circgenetics.108.834564","title":"Distinct Early Signaling Events Resulting From the Expression of the PRKAG2 R302Q Mutant of AMPK Contribute to Increased Myocardial Glycogen","year":2009,"lang":"en","type":"article","venue":"Circulation Cardiovascular Genetics","topic":"Metabolism, Diabetes, and Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Glycogen; Glycogen synthase; Transgene; AMPK; Endocrinology; Biology; Genetically modified mouse; Internal medicine; Downregulation and upregulation; GSK-3; Gene knockdown; Glycogen debranching enzyme; Signal transduction; Phenotype; Protein kinase A; Cell biology; Phosphorylation; Gene; Medicine; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001542449,0.001091555,0.0003166116,0.0002302587,0.0001232437,0.0002648033,0.0002917105,0.0005408162,0.002081226],"category_scores_gemma":[0.0001540011,0.0003076049,0.0003880933,0.0001118838,0.0005297511,0.0002214783,0.0003699159,0.0005813171,0.0006008064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003156836,"about_ca_system_score_gemma":0.0001570803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002434199,"about_ca_topic_score_gemma":0.0004273179,"domain_scores_codex":[0.999864,0.00002202139,0.00001434532,0.00003865059,0.00002723068,0.00003382997],"domain_scores_gemma":[0.9998931,0.00001392764,0.00004069103,0.00001155641,0.000004742335,0.00003597977],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002422254,0.00001667442,0.0004783685,0.00002314085,0.000004268975,0.0003133336,0.000009732339,0.0000495007,0.9984382,0.00004958192,0.00002149892,0.0003534152],"study_design_scores_gemma":[0.000217925,0.0008500181,0.05870797,0.00002694915,0.00006334473,0.004504145,0.00009021658,0.001071459,0.9324688,0.0002261563,0.001752806,0.00002025687],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997022,0.0005676464,0.001319676,0.0000837507,0.00001873168,0.0000282413,0.0002912867,0.00007496968,0.000593706],"genre_scores_gemma":[0.9966015,0.0005331328,0.001157952,0.0001064777,0.00001622098,0.00008216713,0.0005086941,0.00003333809,0.000960392],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002081226,"threshold_uncertainty_score":0.006962359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01047825914336039,"score_gpt":0.2227304002858927,"score_spread":0.2122521411425323,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}