{"id":"W2110625124","doi":"10.1074/mcp.m114.038596","title":"Proteomic Analysis of the Epidermal Growth Factor Receptor (EGFR) Interactome and Post-translational Modifications Associated with Receptor Endocytosis in Response to EGF and Stress","year":2014,"lang":"en","type":"article","venue":"Molecular & Cellular Proteomics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":115,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; Princess Margaret Cancer Centre; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Internalization; Endocytosis; Cell biology; Phosphorylation; Epidermal growth factor; Epidermal growth factor receptor; Anisomycin; Ubiquitin; Clathrin; Chemistry; Biology; Cancer research; Receptor; Kinase; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001528327,0.0003351149,0.0003738662,0.0005597897,0.0003458785,0.000293856,0.000203854,0.0002923576,0.0005949787],"category_scores_gemma":[0.0001120807,0.0001545018,0.0004521783,0.0004481921,0.0001415988,0.0002704116,0.0002311388,0.0003495635,0.0002925913],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002622223,"about_ca_system_score_gemma":0.0002063078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007467467,"about_ca_topic_score_gemma":0.0010305,"domain_scores_codex":[0.9999026,0.000007458904,0.000007035618,0.00002382644,0.00003396253,0.00002511122],"domain_scores_gemma":[0.9999372,0.000007056457,0.00001671243,0.000003475525,0.00001788608,0.00001769058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007953319,0.00001462467,0.000595653,0.00004258997,0.000013961,0.00007735161,0.00002269503,0.00002122764,0.9983922,0.00003881572,0.00003326131,0.0006681797],"study_design_scores_gemma":[0.00002165401,0.0003758609,0.2006408,0.00003040549,0.0001328228,0.002199083,0.0003637378,0.003534439,0.7862495,0.0002087539,0.006204826,0.00003815951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922984,0.002121876,0.003177819,0.00008564724,0.00003402974,0.0000377127,0.001166773,0.00004329023,0.001034338],"genre_scores_gemma":[0.975091,0.004415625,0.009908403,0.0002672859,0.00004759761,0.0001463573,0.004709605,0.00004581059,0.005368283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007467467,"threshold_uncertainty_score":0.001990378,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0081727951160477,"score_gpt":0.2194978177821598,"score_spread":0.2113250226661121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}