{"id":"W2110629166","doi":"10.4049/jimmunol.181.4.2428","title":"Antigen Specificity Acquisition of Adoptive CD4+ Regulatory T Cells via Acquired Peptide-MHC Class I Complexes","year":2008,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Saskatchewan; Saskatchewan Cancer Agency","funders":"University of Saskatchewan","keywords":"MHC class II; Antigen; Adoptive cell transfer; Major histocompatibility complex; MHC class I; Class (philosophy); Biology; MHC restriction; Peptide; Antigen processing; Computational biology; Immunology; Cell biology; Immune system; T cell; Computer science; Biochemistry; Artificial intelligence","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002152269,0.0005273663,0.0002590614,0.0001404106,0.00007992694,0.0003485938,0.0002395555,0.0002441343,0.001192383],"category_scores_gemma":[0.000167766,0.0001944042,0.0002192208,0.00005833219,0.0002033789,0.0002026758,0.0002271649,0.0008857357,0.0003811949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001946672,"about_ca_system_score_gemma":0.0002119826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000159048,"about_ca_topic_score_gemma":0.000226225,"domain_scores_codex":[0.9997148,0.00005525468,0.00001906275,0.00005558463,0.00005528536,0.00009993847],"domain_scores_gemma":[0.9998798,0.00002043057,0.00002978348,0.0000263705,0.00001637313,0.00002727792],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006046806,0.00002969097,0.0001877267,0.00002917958,0.00000359174,0.00004622596,0.00001239371,0.0000545504,0.9975473,0.00007634082,0.00001860894,0.001934015],"study_design_scores_gemma":[0.00005903026,0.001034715,0.003264663,0.00001056047,0.00003316727,0.0005066995,0.00002664211,0.001229995,0.9917854,0.0001071138,0.001937771,0.000004214457],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922226,0.001601312,0.004092317,0.00006117325,0.000037419,0.00004528559,0.00004975779,0.00009910687,0.00179105],"genre_scores_gemma":[0.9955581,0.0004832698,0.00186252,0.0000699692,0.00002774892,0.00002821043,0.0001305257,0.00001545978,0.001824259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001192383,"threshold_uncertainty_score":0.003988922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01698207455298865,"score_gpt":0.2221564061954327,"score_spread":0.205174331642444,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}