{"id":"W2110636497","doi":"10.1046/j.0953-816x.2001.01731.x","title":"Chronic morphine exposure increases the phosphorylation of MAP kinases and the transcription factor CREB in dorsal root ganglion neurons: an in vitro and in vivo study","year":2001,"lang":"en","type":"article","venue":"European Journal of Neuroscience","topic":"Pain Mechanisms and Treatments","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University; McGill University; Douglas Mental Health University Institute; Douglas College","funders":"Canadian Institutes of Health Research; McGill University","keywords":"CREB; Calcitonin gene-related peptide; Dorsal root ganglion; MAPK/ERK pathway; Kinase; Morphine; Neuropeptide; Phosphorylation; p38 mitogen-activated protein kinases; Internal medicine; Endocrinology; Chemistry; Nociception; Protein kinase A; Signal transduction; (+)-Naloxone; Cell biology; Neuroscience; Pharmacology; Biology; Opioid; Transcription factor; Medicine; Spinal cord; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001252271,0.0001317783,0.0002473631,0.0001671487,0.00006715849,0.00003645815,0.0001524685,0.00001201226,0.000003905954],"category_scores_gemma":[0.0001599047,0.00007321077,0.00003694014,0.0003348165,0.0001557111,0.0002839741,0.00002875542,0.0002293497,2.077411e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003004771,"about_ca_system_score_gemma":0.00003756634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008081141,"about_ca_topic_score_gemma":0.0001120056,"domain_scores_codex":[0.9979889,0.0008842736,0.0004429262,0.0002052067,0.0003149809,0.0001637432],"domain_scores_gemma":[0.9994034,0.0001150802,0.0002166275,0.0001634919,0.00003542648,0.00006602595],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001925098,0.0008110654,0.08343799,0.00001618614,0.000004098299,0.001648883,0.001302358,0.0001499197,0.9071925,0.00001143397,0.000003139121,0.003497298],"study_design_scores_gemma":[0.00727405,0.002642238,0.9795597,0.000119227,0.00003537045,0.0004245018,0.0003694286,0.0008116546,0.008594816,0.00002476434,0.00007914305,0.0000651655],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974768,0.001453444,0.0000476692,0.0004803418,0.0001033982,0.0004050641,0.000004177971,0.000004399885,0.00002468654],"genre_scores_gemma":[0.9992587,0.0004438419,0.00002092202,0.000201972,0.00004353739,0.000002125289,3.846192e-7,0.0000128402,0.00001568559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8985977,"threshold_uncertainty_score":0.2985449,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02048111981048124,"score_gpt":0.2510014574531734,"score_spread":0.2305203376426922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}