{"id":"W2110668915","doi":"10.1534/g3.115.016576","title":"Leveraging DNA Damage Response Signaling to Identify Yeast Genes Controlling Genome Stability","year":2015,"lang":"en","type":"article","venue":"G3 Genes Genomes Genetics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Human Genome Research Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Genome instability; Genome; Biology; Genetics; Gene; Saccharomyces cerevisiae; Carcinogenesis; Human genome; Computational biology; Genetic screen; DNA damage; Phenotype; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002261927,0.0003683023,0.0003019347,0.0005867059,0.0001676889,0.0004335899,0.0002577141,0.0002282336,0.0007761606],"category_scores_gemma":[0.0002581041,0.0001354169,0.0002792032,0.0004949447,0.0002255268,0.0002100044,0.0003559315,0.0004305668,0.0003251558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003279099,"about_ca_system_score_gemma":0.0002843942,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001202935,"about_ca_topic_score_gemma":0.003247571,"domain_scores_codex":[0.9998519,0.00001934596,0.00001616838,0.00003488147,0.00005558759,0.00002206576],"domain_scores_gemma":[0.9998129,0.00005878038,0.0000510539,0.00002744031,0.00002446149,0.00002548425],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002903531,0.00001111847,0.0007895677,0.00001980387,0.000004114389,0.00002333062,0.0000106795,0.0001080377,0.9969842,0.00006523787,0.00001503842,0.001939857],"study_design_scores_gemma":[0.000005665457,0.0001326212,0.009407081,0.00000599987,0.00002052375,0.000201024,0.00004055813,0.001705849,0.9866531,0.0001468683,0.001672318,0.00000836215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719973,0.001677175,0.02342876,0.0001297331,0.00001461106,0.00005930038,0.001314669,0.0003759727,0.001002411],"genre_scores_gemma":[0.9754931,0.001534098,0.02032793,0.00009005382,0.000004612877,0.00004190508,0.001361182,0.00007673428,0.001070264],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202935,"threshold_uncertainty_score":0.002596557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03841330450931098,"score_gpt":0.2873527448326468,"score_spread":0.2489394403233359,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}