{"id":"W2110684391","doi":"10.1001/archneur.63.6.883","title":"Preparing for Preventive Clinical Trials","year":2006,"lang":"en","type":"article","venue":"Archives of Neurology","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":293,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; U.S. Public Health Service","keywords":"Disease; Rating scale; Clinical trial; Observational study; Medicine; Huntington's disease; Physical therapy; Psychiatry; Psychology; Internal medicine","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004643959,0.0001272874,0.0004540768,0.00009080087,0.00006360257,0.000008836871,0.0002958028,0.00004059555,0.00001172442],"category_scores_gemma":[0.006610506,0.00011443,0.0003520085,0.00006329752,0.0004029494,0.00003437622,0.0001205528,0.0001070418,0.000005544417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":7.736323e-7,"about_ca_system_score_gemma":0.00004445526,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005380319,"about_ca_topic_score_gemma":0.000008074389,"domain_scores_codex":[0.9959654,0.00231287,0.0008014569,0.0005635053,0.00009894469,0.0002578303],"domain_scores_gemma":[0.9883091,0.01095237,0.0003742934,0.0002896618,0.00001568814,0.0000588316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001049266,0.0004062479,0.009555538,0.00002429165,0.000009905262,0.00000563829,0.00003857735,0.0006019271,0.9685414,0.009746879,0.001143554,0.00887682],"study_design_scores_gemma":[0.001320222,0.001100786,0.06996561,0.000004354415,0.00004545217,0.000009110522,0.000001721729,0.001427568,0.8821675,0.03920268,0.004639169,0.0001158681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9893402,0.00003254695,0.004436238,0.0003739213,0.00038356,0.0007530795,0.00007381532,0.00003685123,0.00456981],"genre_scores_gemma":[0.9977469,0.00002509297,0.0009024026,0.0007291748,0.0002090333,0.00008239428,0.000004279078,0.00001946582,0.0002812662],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0863739,"threshold_uncertainty_score":0.7913871,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1172262575654196,"score_gpt":0.4128400064981013,"score_spread":0.2956137489326817,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}