{"id":"W2110705119","doi":"10.1074/jbc.m602815200","title":"c-Jun N-terminal Kinase-mediated Stabilization of Microsomal Prostaglandin E2 Synthase-1 mRNA Regulates Delayed Microsomal Prostaglandin E2 Synthase-1 Expression and Prostaglandin E2 Biosynthesis by Cardiomyocytes","year":2006,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital; Toronto General Hospital; University of Toronto; University Health Network","funders":"Medical Research Council; Canadian Institutes of Health Research; Pfizer; Karolinska Institutet; Heart and Stroke Foundation of Canada; Reumatikerförbundet","keywords":"Prostaglandin E2; Messenger RNA; ATP synthase; Phosphorylation; Prostaglandin E; Prostaglandin; Kinase; Biology; Protein kinase A; Molecular biology; Chemistry; Endocrinology; Enzyme; Cell biology; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002046712,0.0005503753,0.0003806667,0.0002247534,0.0002249575,0.0002840956,0.0001867069,0.000218829,0.001801741],"category_scores_gemma":[0.0001400516,0.0002048596,0.0003931306,0.0001170567,0.0003366431,0.0002822396,0.0002301018,0.000629703,0.0005732286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003115922,"about_ca_system_score_gemma":0.0003410979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003256804,"about_ca_topic_score_gemma":0.0006413128,"domain_scores_codex":[0.9998521,0.00001824491,0.00001407756,0.00003833955,0.00002297605,0.00005428609],"domain_scores_gemma":[0.9998672,0.00001181049,0.0000396981,0.00001185364,0.00001623485,0.00005317571],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004746652,0.00003706029,0.000162607,0.00006878685,0.000004328461,0.00005530431,0.00001556862,0.00003610753,0.998369,0.00006118029,0.00004623872,0.0006691934],"study_design_scores_gemma":[0.0001070067,0.0005517961,0.01738432,0.00001571539,0.00003189435,0.0003779525,0.00009201623,0.001149319,0.9778036,0.0001010803,0.002372086,0.00001311384],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908359,0.003544086,0.002814664,0.0001625883,0.0001398717,0.00006502442,0.0005662654,0.00008062854,0.001790928],"genre_scores_gemma":[0.9878819,0.002598779,0.003002919,0.000137466,0.0000755447,0.0001567952,0.0009845466,0.00003564605,0.005126424],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001801741,"threshold_uncertainty_score":0.0060274,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008427771521843057,"score_gpt":0.2260391842632206,"score_spread":0.2176114127413775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}