{"id":"W2110712160","doi":"10.4049/jimmunol.168.9.4737","title":"SHIP Negatively Regulates IgE + Antigen-Induced IL-6 Production in Mast Cells by Inhibiting NF-κB Activity","year":2002,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":135,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; BC Cancer Agency","funders":"National Cancer Institute; Michael Smith Health Research BC","keywords":"Transactivation; p38 mitogen-activated protein kinases; Cell biology; Kinase; Signal transduction; Phosphatidylinositol; Protein kinase B; Phosphorylation; Immunoglobulin E; MAPK/ERK pathway; Biology; Protein kinase A; Chemistry; Biochemistry; Immunology; Antibody; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009503906,0.0002159391,0.0004579212,0.000222658,0.0002411493,0.00001330222,0.000350509,0.0002741414,0.0006616082],"category_scores_gemma":[0.0001412968,0.0001555232,0.00009656874,0.000258389,0.0003627824,0.0002062027,0.00009037549,0.001032346,0.0001441195],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009254322,"about_ca_system_score_gemma":0.000033092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001577224,"about_ca_topic_score_gemma":0.00005629907,"domain_scores_codex":[0.9979517,0.0007785364,0.000580635,0.0001888092,0.00005675047,0.0004435217],"domain_scores_gemma":[0.9988291,0.0002228451,0.0005586515,0.0002356102,0.0001356126,0.00001813434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003855126,0.0002575609,0.0001932081,0.000009598175,0.0001394252,0.000009720668,0.001788635,0.00001191181,0.9835144,0.00004067248,0.002344305,0.01130506],"study_design_scores_gemma":[0.001175961,0.000509163,0.004014596,0.00006451682,0.00003167931,0.0005616613,0.0007271644,0.000006850107,0.9862124,0.00008241389,0.006451635,0.0001619076],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908733,0.00538119,0.00002899109,0.001813964,0.001099321,0.0001691959,0.000008458666,0.00001686693,0.000608736],"genre_scores_gemma":[0.9958248,0.001254147,0.00002800767,0.00005560519,0.00008197501,0.000002154146,0.000003563552,0.00002014911,0.002729584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01114315,"threshold_uncertainty_score":0.7244145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01872547594162029,"score_gpt":0.2134500961352965,"score_spread":0.1947246201936762,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}