{"id":"W2110761051","doi":"10.1101/gad.1321305","title":"Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway","year":2005,"lang":"en","type":"article","venue":"Genes & Development","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Institute on Aging; Ellison Medical Foundation; National Aeronautics and Space Administration; National Cancer Institute; National Institutes of Health; Abraham J. and Phyllis Katz Foundation; American Cancer Society","keywords":"Telomere; Biology; Genome instability; Chromosome instability; Sister chromatids; Helicase; Telomerase; RecQ helicase; Premature aging; Chromatid; Genetics; Werner syndrome; Telomere-binding protein; Senescence; Cell biology; Cancer research; Molecular biology; Chromosome; DNA damage; DNA; Gene; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007520769,0.0004714672,0.0005995772,0.0003572131,0.0002886349,0.00004340649,0.0003126496,0.0002037159,0.0003565746],"category_scores_gemma":[0.0001115658,0.0003680206,0.000106293,0.0008832629,0.0001820077,0.0001827736,0.0002649142,0.0004037456,0.00007226756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003563477,"about_ca_system_score_gemma":0.0006727606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001382313,"about_ca_topic_score_gemma":0.0002440378,"domain_scores_codex":[0.9963527,0.0002065171,0.00106775,0.0008306112,0.0009277682,0.0006146759],"domain_scores_gemma":[0.998422,0.0001703692,0.0003643729,0.0005495984,0.0002876288,0.000206091],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002177356,0.001039592,0.1372618,0.0002846188,0.0001608984,0.0000234633,0.004128743,0.00007638154,0.5317871,0.0002480025,0.0004452867,0.3243263],"study_design_scores_gemma":[0.001631118,0.00008987741,0.4082089,0.0003737075,0.00004579452,0.0000221746,0.0006776534,0.0002618504,0.5684389,0.0001113381,0.01974843,0.0003902144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941063,0.002263158,0.00008012239,0.001313737,0.0005520314,0.001151577,0.00003859534,0.00008354845,0.0004109448],"genre_scores_gemma":[0.990213,0.0006708877,0.007747445,0.0003903874,0.0001250967,0.0001042782,0.00008997782,0.00004909135,0.000609886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3239361,"threshold_uncertainty_score":0.9998772,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01671394120778819,"score_gpt":0.2273817481567857,"score_spread":0.2106678069489975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}