{"id":"W2110761051","doi":"10.1101/gad.1321305","title":"Elevated telomere-telomere recombination in WRN-deficient, telomere dysfunctional cells promotes escape from senescence and engagement of the ALT pathway","year":2005,"lang":"en","type":"article","venue":"Genes & Development","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":189,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Hôtel-Dieu de Québec","funders":"National Institute on Aging; Ellison Medical Foundation; National Aeronautics and Space Administration; National Cancer Institute; National Institutes of Health; Abraham J. and Phyllis Katz Foundation; American Cancer Society","keywords":"Telomere; Biology; Genome instability; Chromosome instability; Sister chromatids; Helicase; Telomerase; RecQ helicase; Premature aging; Chromatid; Genetics; Werner syndrome; Telomere-binding protein; Senescence; Cell biology; Cancer research; Molecular biology; Chromosome; DNA damage; DNA; Gene; DNA-binding protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001323764,0.0001966313,0.0001796441,0.0001811381,0.00009158566,0.0002958265,0.00007954002,0.0001220213,0.00103148],"category_scores_gemma":[0.0001250528,0.00008311751,0.0001219802,0.0001165358,0.0001458758,0.0001427557,0.0001787854,0.0003382328,0.0002679269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001367292,"about_ca_system_score_gemma":0.00008770918,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001900116,"about_ca_topic_score_gemma":0.0002918174,"domain_scores_codex":[0.9999163,0.00001718454,0.00001237126,0.00001639823,0.00002031585,0.00001745117],"domain_scores_gemma":[0.9999087,0.00001057508,0.00002533013,0.000020805,0.000006241691,0.00002837243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000430209,0.000006517659,0.0003681837,0.000008825384,0.000002815752,0.00004296211,0.00000850939,0.00002326729,0.9988696,0.00006911573,0.00001088449,0.0005462926],"study_design_scores_gemma":[0.00001471982,0.0002898978,0.01011669,0.000004697681,0.00001319549,0.0008163269,0.00004112857,0.0008572465,0.9856451,0.000108213,0.002089151,0.000003712098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977222,0.0004702075,0.001254978,0.00002319626,0.000006691388,0.000005076252,0.0001079181,0.00004878245,0.0003610237],"genre_scores_gemma":[0.9985306,0.0002048045,0.0004465787,0.000008970967,0.00000299721,0.000005150969,0.0001629992,0.000005266491,0.0006326438],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103148,"threshold_uncertainty_score":0.003450692,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01671394120778819,"score_gpt":0.2273817481567857,"score_spread":0.2106678069489975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}