{"id":"W2110776599","doi":"10.1126/science.1184208","title":"Regulation of Alternative Splicing by Histone Modifications","year":2010,"lang":"en","type":"article","venue":"Science","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"RNA splicing; Histone code; Alternative splicing; Histone; Histone H2A; Histone methylation; Biology; Histone methyltransferase; Cell biology; Splicing factor; Histone H1; Genetics; Messenger RNA; Gene; Nucleosome; Gene expression; DNA methylation; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003020404,0.0002101635,0.0001585177,0.0002149015,0.0001458509,0.0005539126,0.0002016678,0.0002579395,0.001139302],"category_scores_gemma":[0.0002522199,0.0001520517,0.0002284705,0.0002354005,0.0003456702,0.0004194565,0.0003451997,0.0003348955,0.0005417598],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003117616,"about_ca_system_score_gemma":0.00009388752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003095274,"about_ca_topic_score_gemma":0.0004952441,"domain_scores_codex":[0.9997491,0.00004488654,0.0000152648,0.00007228318,0.00007514356,0.00004329807],"domain_scores_gemma":[0.9998177,0.00002991979,0.000061502,0.00002097483,0.00003996008,0.00002997734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002100522,0.00002206457,0.003779319,0.00009955744,0.00002638608,0.0002996648,0.0001181539,0.0001951725,0.9650379,0.003622721,0.0004231672,0.02616586],"study_design_scores_gemma":[0.00005856764,0.0003112081,0.1028732,0.00005355502,0.00005179402,0.001934316,0.0002445031,0.003637776,0.8476607,0.008538377,0.0345863,0.00004956077],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9290524,0.03106126,0.02304265,0.001142008,0.0003130915,0.00003516653,0.0004380977,0.0001668908,0.01474845],"genre_scores_gemma":[0.9859267,0.006284772,0.002848946,0.0002220998,0.00008640638,0.000009630586,0.0002525263,0.00002231102,0.004346585],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001139302,"threshold_uncertainty_score":0.003811359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01305817906043518,"score_gpt":0.3211253411243379,"score_spread":0.3080671620639028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}