{"id":"W2110776599","doi":"10.1126/science.1184208","title":"Regulation of Alternative Splicing by Histone Modifications","year":2010,"lang":"en","type":"article","venue":"Science","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"RNA splicing; Histone code; Alternative splicing; Histone; Histone H2A; Histone methylation; Biology; Histone methyltransferase; Cell biology; Splicing factor; Histone H1; Genetics; Messenger RNA; Gene; Nucleosome; Gene expression; DNA methylation; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002586594,0.00003022741,0.00003163676,0.00003673706,0.0000923418,0.00001032451,0.0002085209,0.00002041545,0.000009697714],"category_scores_gemma":[0.0001545519,0.00002753249,0.00001314157,0.0001414702,0.000341874,0.00000610777,0.00004522915,0.00004658625,0.000003215856],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006956926,"about_ca_system_score_gemma":0.00007245949,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006095318,"about_ca_topic_score_gemma":0.00002130665,"domain_scores_codex":[0.9995018,0.000006206039,0.00006809963,0.0001546864,0.0001565833,0.0001126479],"domain_scores_gemma":[0.9995866,0.000004534649,0.00003846587,0.0002081346,0.0001121153,0.00005012984],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000003056071,0.000009800083,0.0003596029,0.000001177179,8.941943e-7,2.947696e-8,0.00002013089,0.0000272152,0.9971406,0.000633497,0.0002182488,0.001585788],"study_design_scores_gemma":[0.00005829451,0.00003072336,0.006477213,0.00000182452,6.481059e-7,0.000001206266,0.00001471252,0.002088508,0.9895143,0.0001565952,0.001623443,0.00003252426],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940971,0.00003405832,0.003833856,0.0001122922,0.00006035732,0.00005124192,0.000004226788,0.000002471963,0.001804363],"genre_scores_gemma":[0.9968011,0.000008411559,0.001247767,0.00001766303,0.00002971388,0.000003404509,0.00000623734,0.000002346261,0.001883379],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007626253,"threshold_uncertainty_score":0.1259649,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01305817906043518,"score_gpt":0.3211253411243379,"score_spread":0.3080671620639028,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}