{"id":"W2110822080","doi":"10.1101/gad.200436.112","title":"The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling","year":2012,"lang":"en","type":"article","venue":"Genes & Development","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; McGill University","keywords":"Biology; Corticotropic cell; Enhancer; Transcription factor; Cell biology; Chromatin; Chromatin remodeling; Anterior pituitary; Genetics; Gene; Endocrinology; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001160409,0.0001891164,0.0001245296,0.0002028693,0.000159131,0.0003117096,0.0001698463,0.0001352436,0.001438465],"category_scores_gemma":[0.0001205768,0.0001624285,0.0001325735,0.00008849891,0.0003189487,0.0002609543,0.0003076568,0.0002481437,0.0004185558],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002410684,"about_ca_system_score_gemma":0.0001978496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003425331,"about_ca_topic_score_gemma":0.001095036,"domain_scores_codex":[0.999916,0.00001004836,0.000003475491,0.00002415422,0.00002569988,0.00002063679],"domain_scores_gemma":[0.999927,0.00001887614,0.00001439595,0.000008574596,0.000009257221,0.00002181496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003463049,0.000002324547,0.0006322461,0.000008798908,0.000002364985,0.00005944718,0.00001492427,0.00004602838,0.996179,0.000789865,0.00002914244,0.002201147],"study_design_scores_gemma":[0.00001641921,0.00008831482,0.01241716,0.000007074614,0.00001232704,0.0004468538,0.00008405693,0.001506635,0.9797569,0.0006412974,0.005013905,0.000008964413],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9800717,0.001225355,0.01347214,0.0001076287,0.00002657233,0.00001591293,0.0002624739,0.0001932114,0.004625066],"genre_scores_gemma":[0.9928454,0.0006243602,0.003461728,0.00003651397,0.0000101698,0.00001339233,0.0002797674,0.00004267845,0.002685993],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001438465,"threshold_uncertainty_score":0.004812181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01734331792492033,"score_gpt":0.2418601524249305,"score_spread":0.2245168345000102,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}