{"id":"W2110859705","doi":"10.1128/aac.49.12.4834-4842.2005","title":"Biphenylsulfonacetic Acid Inhibitors of the Human Papillomavirus Type 6 E1 Helicase Inhibit ATP Hydrolysis by an Allosteric Mechanism Involving Tyrosine 486","year":2005,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Cervical Cancer and HPV Research","field":"Medicine","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Boehringer Ingelheim (Canada)","funders":"","keywords":"Allosteric regulation; Helicase; Enzyme; Tyrosine; Biochemistry; ATPase; Biology; Chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001555389,0.0002306535,0.0003895378,0.00007964828,0.0002055677,0.0000481167,0.000181494,0.0001363145,0.001527296],"category_scores_gemma":[0.00001094997,0.0001641963,0.0001347342,0.0003635577,0.0001679494,0.0001148793,0.0001106071,0.0002256882,0.00001293529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006333873,"about_ca_system_score_gemma":0.00004792894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002278722,"about_ca_topic_score_gemma":0.0000540369,"domain_scores_codex":[0.9985461,0.00004989583,0.000356495,0.0003749767,0.0003254728,0.0003471204],"domain_scores_gemma":[0.9991871,0.00001143608,0.0001105081,0.0003831063,0.0001234779,0.0001844192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002354236,0.0004630905,0.003038637,0.00009686589,0.00008066546,0.000004493747,0.0006596632,9.308091e-7,0.9664617,0.00003538113,0.008986133,0.01993703],"study_design_scores_gemma":[0.003804978,0.0005379205,0.01419163,0.00009869618,0.00009267501,0.00003061556,0.00006199204,0.0001683278,0.9480851,0.00006695053,0.03259141,0.0002696642],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931563,0.0004366189,0.000009500754,0.005517199,0.00007396626,0.0003779565,0.00002747142,0.00003283955,0.0003681889],"genre_scores_gemma":[0.9852062,0.00154085,0.0001252004,0.01201817,0.0002768592,0.000005501792,0.00004024165,0.00005049743,0.0007364893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02360527,"threshold_uncertainty_score":0.9993854,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02122004904979845,"score_gpt":0.2942993303545496,"score_spread":0.2730792813047512,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}