{"id":"W2110870445","doi":"10.3899/jrheum.121012","title":"Cardiovascular Events Are Not Associated with <i>MTHFR</i> Polymorphisms, But Are Associated with Methotrexate Use and Traditional Risk Factors in US Veterans with Rheumatoid Arthritis","year":2013,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institutes of Health; University of Colorado Denver; U.S. Department of Veterans Affairs","keywords":"Medicine; Methylenetetrahydrofolate reductase; Rheumatoid arthritis; Methotrexate; Antifolate; Internal medicine; Veterans Affairs; Arthritis; Physical therapy; Oncology; Antimetabolite; Allele; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006717978,0.0002252455,0.0002763583,0.0003833818,0.0002358327,0.000438362,0.0002368468,0.0003654588,0.001756172],"category_scores_gemma":[0.002610289,0.0001656553,0.0005172692,0.0007066096,0.0002019362,0.0001641757,0.0002140914,0.0005386699,0.0001745352],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001673094,"about_ca_system_score_gemma":0.0002080963,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003173627,"about_ca_topic_score_gemma":0.003951853,"domain_scores_codex":[0.9994549,0.0001566922,0.00007628406,0.0001092075,0.0001264535,0.00007649847],"domain_scores_gemma":[0.9975151,0.0004191292,0.001573278,0.0001386968,0.0001628133,0.0001910696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001843822,0.00001859096,0.9977992,0.000009264263,0.0001097407,0.00004828783,0.0000165217,0.00002828842,0.0002844808,0.00001046249,0.00005488468,0.001435976],"study_design_scores_gemma":[0.00001140773,0.00007405864,0.9992605,0.000006450279,0.00006660712,0.0002806967,0.00001791187,0.0001142486,0.00006149504,0.00001942682,0.00008578287,0.000001501102],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976927,0.001187193,0.0001483298,0.0001107933,0.00001257106,0.000005551727,0.000323314,0.000005782095,0.0005136766],"genre_scores_gemma":[0.9994362,0.0001881374,0.00005860954,0.00002161453,0.00002779413,0.000002486976,0.0001862453,0.000001059721,0.00007792364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003173627,"threshold_uncertainty_score":0.006310284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03026205744101377,"score_gpt":0.2330059210562787,"score_spread":0.2027438636152649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}