{"id":"W2110873152","doi":"10.1016/j.jmb.2012.03.020","title":"Crystal Structure of Bacillus subtilis Signal Peptide Peptidase A","year":2012,"lang":"en","type":"article","venue":"Journal of Molecular Biology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"National Research Council Canada; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC; Iowa State University","keywords":"Bacillus subtilis; Archaea; Signal peptide; Catalytic triad; Signal peptidase; Chemistry; Protease; Histone octamer; Serine protease; Biochemistry; Biology; Crystallography; Active site; Stereochemistry; Peptide sequence; Enzyme; Bacteria; Nucleosome; DNA; Histone; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002358841,0.0001375778,0.0004866424,0.000287286,0.00002401221,0.000004282359,0.00008918253,0.0001523286,0.001182942],"category_scores_gemma":[0.0001502661,0.0001001486,0.00042341,0.0001898957,0.0001354963,0.00006663876,0.00003148297,0.0002919816,0.000006497861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004104484,"about_ca_system_score_gemma":0.0001026598,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007716156,"about_ca_topic_score_gemma":0.000002053455,"domain_scores_codex":[0.9987643,0.0001310425,0.0005368431,0.00009603334,0.000214762,0.000257041],"domain_scores_gemma":[0.9987937,0.00003703544,0.0004370676,0.0001539685,0.0003113783,0.0002668285],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001760176,0.0001456431,0.00771217,0.00003264472,0.00024187,0.00009812183,0.0001171591,0.00001070261,0.9900953,0.0002386902,0.0005372959,0.0005943688],"study_design_scores_gemma":[0.00308558,0.001395409,0.008988152,0.0003069111,0.0005247211,0.003175558,0.0003907443,0.00004811776,0.9771419,0.0005883326,0.00412773,0.0002268793],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993342,0.0006619758,0.004878297,0.0004326604,0.00005029388,0.00005521607,0.00003481268,0.000005680393,0.0005390984],"genre_scores_gemma":[0.9964551,0.0000150382,0.002546194,0.0005786257,0.0002879416,3.433243e-7,0.0000235708,0.00001251093,0.00008069345],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01295345,"threshold_uncertainty_score":0.9997301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0102662619070043,"score_gpt":0.2772226718105406,"score_spread":0.2669564099035363,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}