{"id":"W2110882632","doi":"10.4049/jimmunol.167.5.2547","title":"Bidirectional Negative Regulation of Human T and Dendritic Cells by CD47 and Its Cognate Receptor Signal-Regulator Protein-α: Down-Regulation of IL-12 Responsiveness and Inhibition of Dendritic Cell Activation","year":2001,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":232,"is_retracted":false,"has_abstract":true,"ca_institutions":"Research & Development Corporation; Hôpital Notre-Dame; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"","keywords":"Cell biology; CD47; Biology; Proinflammatory cytokine; T cell; Immune system; Dendritic cell; Interleukin 10; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001461906,0.0003267886,0.0002252902,0.0001349114,0.0001077527,0.0003717774,0.0001323749,0.0001748912,0.0009613713],"category_scores_gemma":[0.0001598682,0.0001236568,0.0001894627,0.0001388723,0.0002405674,0.0001526923,0.0002249884,0.0003868527,0.0005078756],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002429397,"about_ca_system_score_gemma":0.0001973436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001763216,"about_ca_topic_score_gemma":0.0001960805,"domain_scores_codex":[0.9997501,0.00007161283,0.00001889749,0.00003412261,0.00004539594,0.00007983405],"domain_scores_gemma":[0.9998941,0.00002222515,0.00003440222,0.00001505208,0.00001061903,0.00002348752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003309729,0.00003623298,0.0002571926,0.00003515695,0.000005468302,0.00005518294,0.00001028872,0.00004230893,0.9973881,0.0001478872,0.00008182379,0.00160942],"study_design_scores_gemma":[0.00005102793,0.0001831985,0.002614646,0.000005190612,0.00001790652,0.0003556036,0.00001809764,0.001029036,0.9928202,0.00004751225,0.002854905,0.000002640877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922998,0.003409388,0.002304559,0.0001478047,0.00004212896,0.00002634211,0.00012715,0.00006426515,0.001578625],"genre_scores_gemma":[0.9963456,0.001033177,0.001237024,0.00006714809,0.00002241678,0.00003438552,0.0002386573,0.00001309614,0.001008465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009613713,"threshold_uncertainty_score":0.003216088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097194888934725,"score_gpt":0.2262720894247379,"score_spread":0.2153001405353907,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}