{"id":"W2110905825","doi":"10.1111/mmi.12298","title":"Gene expression modulation and the molecular mechanisms involved in <scp>N</scp>elfinavir resistance in <i><scp>L</scp>eishmania donovani</i> axenic amastigotes","year":2013,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs","keywords":"Biology; Amastigote; Gene expression profiling; Gene; Molecular biology; Axenic; Gene expression; Genetics; Cell biology; Leishmania; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0009292593,0.0005151901,0.0009537992,0.0004715253,0.0001545063,0.00007901638,0.0004273695,0.0004266664,0.00001182455],"category_scores_gemma":[0.002672239,0.0003972023,0.0001714499,0.00069612,0.0006146383,0.0001669234,0.0005618435,0.0007642946,0.00006148527],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001912038,"about_ca_system_score_gemma":0.00009419958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002393293,"about_ca_topic_score_gemma":0.0003620754,"domain_scores_codex":[0.9960054,0.0008613581,0.0007952666,0.001032426,0.0002723528,0.001033172],"domain_scores_gemma":[0.997444,0.001018033,0.000258337,0.0008404229,0.0002712682,0.000167974],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005827565,0.0001564332,0.001953447,0.00009682443,0.00008548758,0.000247458,0.0008584111,0.00006715594,0.9928917,0.001661627,0.001762231,0.0001609353],"study_design_scores_gemma":[0.00939864,0.0003159788,0.02382684,0.0004073867,0.00007122941,0.0001162496,0.001500044,0.0005815569,0.945847,0.01236358,0.005374997,0.0001964324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9774951,0.01292965,0.004852509,0.001565416,0.0001173128,0.002174732,0.00001574343,0.00007459024,0.0007749923],"genre_scores_gemma":[0.9871584,0.0008660883,0.00927712,0.001579848,0.00004055001,0.0004579592,0.0001204969,0.00008580543,0.0004137687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04704465,"threshold_uncertainty_score":0.999848,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007481165737309,"score_gpt":0.2347710005970854,"score_spread":0.2246961889397123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}