{"id":"W2110905825","doi":"10.1111/mmi.12298","title":"Gene expression modulation and the molecular mechanisms involved in <scp>N</scp>elfinavir resistance in <i><scp>L</scp>eishmania donovani</i> axenic amastigotes","year":2013,"lang":"en","type":"article","venue":"Molecular Microbiology","topic":"Research on Leishmaniasis Studies","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; National Institutes of Health; Canada Research Chairs","keywords":"Biology; Amastigote; Gene expression profiling; Gene; Molecular biology; Axenic; Gene expression; Genetics; Cell biology; Leishmania; Parasite hosting","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005870295,0.000160128,0.0001520862,0.0001667524,0.000103385,0.0002151116,0.00009486441,0.000208551,0.0006183759],"category_scores_gemma":[0.00007721669,0.00009375314,0.0001928726,0.0001737572,0.0002045344,0.000141754,0.00008670471,0.0002580227,0.0002022403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001871873,"about_ca_system_score_gemma":0.00009864573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004859695,"about_ca_topic_score_gemma":0.0004991043,"domain_scores_codex":[0.9999237,0.000009142878,0.00000481042,0.00002795851,0.00001110101,0.00002334257],"domain_scores_gemma":[0.999954,0.00001405201,0.00001343804,0.000004147104,0.000007666074,0.000006747625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000677727,0.000006871767,0.0002464857,0.00001450716,0.000001150005,0.00002506775,0.000008520668,0.00002436701,0.9989505,0.00003827321,0.000009992069,0.0006064935],"study_design_scores_gemma":[0.00002145163,0.0005178449,0.0839521,0.00001422521,0.00002536571,0.0004854178,0.0001428034,0.001634902,0.9098821,0.0001887278,0.003125143,0.000009926832],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959729,0.001232781,0.001222425,0.00009414621,0.000007573569,0.00001682497,0.0007627464,0.00002713723,0.0006634482],"genre_scores_gemma":[0.9945627,0.0008000849,0.001267756,0.0000685765,0.000009290312,0.00004756615,0.001125908,0.00001038648,0.002107907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006183759,"threshold_uncertainty_score":0.002068639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01007481165737309,"score_gpt":0.2347710005970854,"score_spread":0.2246961889397123,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}