{"id":"W2110935876","doi":"10.1186/gm542","title":"Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids","year":2014,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill Genome Centre; McGill University; Memorial University of Newfoundland","funders":"National Eye Institute; Weill Cornell Medical College; National Institutes of Health; Helmholtz Zentrum München; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; King's College London; Münchner Zentrum für Gesundheitswissenschaften; Weill Cornell Medicine - Qatar; Wellcome Trust; Qatar Foundation; Helsingin Yliopisto; Oak Foundation","keywords":"Mendelian randomization; Metabolome; Biology; Metabolite; Single-nucleotide polymorphism; Genetics; Metabolomics; Quantitative trait locus; Computational biology; Bioinformatics; Genotype; Biochemistry; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007847353,0.0005634661,0.0004569366,0.001505283,0.0004508701,0.0008091955,0.0005972568,0.000539339,0.002018293],"category_scores_gemma":[0.01579041,0.0002186612,0.001871285,0.001462751,0.001007127,0.0005298621,0.0007399487,0.0009569456,0.0001043619],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005260349,"about_ca_system_score_gemma":0.001706601,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003042991,"about_ca_topic_score_gemma":0.00272873,"domain_scores_codex":[0.9971631,0.001547954,0.0001797272,0.0007181234,0.0002374405,0.000153638],"domain_scores_gemma":[0.9769936,0.01885055,0.002400925,0.00102606,0.0003526999,0.0003761488],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007358658,0.0001806452,0.9546701,0.0001572394,0.002264419,0.0002712755,0.0001753594,0.00732648,0.008765613,0.002805906,0.000237875,0.02240921],"study_design_scores_gemma":[0.0002322058,0.0008275292,0.8625242,0.00008328199,0.003012745,0.0009194011,0.0003660794,0.08792363,0.01026149,0.03203742,0.001745109,0.00006694091],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9547062,0.0006179563,0.04292442,0.000455952,0.0000152516,0.00005537716,0.0007823763,0.00008554119,0.0003569676],"genre_scores_gemma":[0.9870366,0.0001698643,0.01208463,0.0001105854,0.00001590187,0.00004147159,0.0004722678,0.000009533119,0.000059149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007847353,"threshold_uncertainty_score":0.04150128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01614000991523457,"score_gpt":0.226118166941261,"score_spread":0.2099781570260264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}