{"id":"W2110935876","doi":"10.1186/gm542","title":"Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids","year":2014,"lang":"en","type":"article","venue":"Genome Medicine","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University and Génome Québec Innovation Centre; McGill Genome Centre; McGill University; Memorial University of Newfoundland","funders":"National Eye Institute; Weill Cornell Medical College; National Institutes of Health; Helmholtz Zentrum München; National Institute for Health and Care Research; Bundesministerium für Bildung und Forschung; King's College London; Münchner Zentrum für Gesundheitswissenschaften; Weill Cornell Medicine - Qatar; Wellcome Trust; Qatar Foundation; Helsingin Yliopisto; Oak Foundation","keywords":"Mendelian randomization; Metabolome; Biology; Metabolite; Single-nucleotide polymorphism; Genetics; Metabolomics; Quantitative trait locus; Computational biology; Bioinformatics; Genotype; Biochemistry; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006023363,0.0002545211,0.0003953675,0.0001053606,0.0001753209,0.00002385544,0.0001800221,0.0001084944,0.00003071862],"category_scores_gemma":[0.0004377772,0.0002171392,0.00005456433,0.0001467762,0.0001380024,0.000002790814,0.0002845022,0.0001494319,0.000003835906],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001176167,"about_ca_system_score_gemma":0.0000243556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000431391,"about_ca_topic_score_gemma":0.0000391027,"domain_scores_codex":[0.9984425,0.0001025312,0.0003853979,0.00052148,0.0001471634,0.0004009764],"domain_scores_gemma":[0.9992139,0.00003761386,0.0001565475,0.0003647671,0.00008340149,0.0001438137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00001012758,0.00001467764,0.002145146,0.00005432658,0.0001129195,0.000004403078,0.0004236225,0.00001744761,0.9886503,0.001045368,0.00002254335,0.007499157],"study_design_scores_gemma":[0.0191977,0.008210505,0.4036817,0.0009181009,0.002200586,0.001265323,0.006513863,0.01410553,0.2659836,0.01003086,0.262291,0.005601273],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9627172,0.01328652,0.02031034,0.0002415666,0.0003218653,0.0001685023,0.000007397355,0.00002545683,0.002921104],"genre_scores_gemma":[0.9894016,0.0009019183,0.007227354,0.0006136071,0.00158102,0.00001654885,0.00008415183,0.0000385122,0.0001352416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7226667,"threshold_uncertainty_score":0.885468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01614000991523457,"score_gpt":0.226118166941261,"score_spread":0.2099781570260264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}