{"id":"W2110939349","doi":"10.1002/pro.479","title":"Thermal unfolding studies show the disease causing F508del mutation in CFTR thermodynamically destabilizes nucleotide‐binding domain 1","year":2010,"lang":"en","type":"article","venue":"Protein Science","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hospital for Sick Children; University of Toronto","keywords":"Chemistry; Equilibrium unfolding; Crystallography; Circular dichroism; Cyclic nucleotide-binding domain; Biophysics; Protein folding; Nucleotide; Folding (DSP implementation); Biochemistry; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002072678,0.0003469864,0.000285693,0.0001433674,0.0002944719,0.0001584488,0.0001991021,0.0002639991,0.002671829],"category_scores_gemma":[0.0003607549,0.0001365022,0.0002728348,0.0002036836,0.0003031901,0.0002048154,0.0001975957,0.0005273484,0.0004234802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002586557,"about_ca_system_score_gemma":0.0001470514,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008104645,"about_ca_topic_score_gemma":0.001000248,"domain_scores_codex":[0.9998035,0.00003412759,0.00001253397,0.0000659178,0.00006043053,0.00002353644],"domain_scores_gemma":[0.9998112,0.00004892671,0.00005790934,0.00002023895,0.00003640206,0.00002530388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006470647,0.00003091099,0.001263302,0.00003437748,0.00001418389,0.00003711467,0.0000629259,0.0001965007,0.9965659,0.0001356173,0.00009993161,0.00149456],"study_design_scores_gemma":[0.000007352964,0.0002487489,0.02146701,0.00001012101,0.00001954081,0.0003974179,0.00004690772,0.002887966,0.9728606,0.0001616164,0.001875833,0.00001703753],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854969,0.0007120166,0.01069103,0.000109209,0.0000258211,0.00003975999,0.0005646958,0.0001328497,0.002227624],"genre_scores_gemma":[0.9936529,0.0003180647,0.003777742,0.00007414982,0.00000597564,0.00005102243,0.0006116952,0.00002959357,0.001478829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002671829,"threshold_uncertainty_score":0.008938193,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02635306478729215,"score_gpt":0.3474896592070595,"score_spread":0.3211365944197674,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}