{"id":"W2110949408","doi":"10.1158/1078-0432.ccr-13-3389","title":"Dual mTORC1/2 Blockade Inhibits Glioblastoma Brain Tumor Initiating Cells <i>In Vitro</i> and <i>In Vivo</i> and Synergizes with Temozolomide to Increase Orthotopic Xenograft Survival","year":2014,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Calgary","funders":"American Association for Cancer Research","keywords":"Temozolomide; In vivo; Glioblastoma; Blockade; In vitro; mTORC1; Medicine; Cancer research; Pharmacology; Chemistry; Internal medicine; Biology; PI3K/AKT/mTOR pathway; Apoptosis; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001683168,0.0007335655,0.0006663469,0.0003809563,0.0001715441,0.000378296,0.0002569741,0.0001939065,0.0008965193],"category_scores_gemma":[0.00007907845,0.0001446541,0.0003440104,0.0002135782,0.0002021121,0.0001856384,0.0001201859,0.0007836198,0.0002858911],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005213815,"about_ca_system_score_gemma":0.0004772662,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001225399,"about_ca_topic_score_gemma":0.003610393,"domain_scores_codex":[0.9998573,0.00001661715,0.00001526814,0.00002000326,0.00003835994,0.00005245043],"domain_scores_gemma":[0.9999371,0.000006674652,0.00001526371,0.000007220565,0.000006514918,0.00002723064],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001261818,0.0007771245,0.0005662644,0.00009430759,0.00004833252,0.00004554997,0.00001512623,0.0004114288,0.9891594,0.0001203659,0.0005793803,0.006920849],"study_design_scores_gemma":[0.0003647746,0.007325964,0.008666479,0.00001212052,0.0001144756,0.000356034,0.00002355509,0.002278741,0.97809,0.00003997455,0.002718708,0.000009197424],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954038,0.00138116,0.0005578931,0.0001065942,0.00004615594,0.00006230621,0.0004397333,0.0001466374,0.001855772],"genre_scores_gemma":[0.9953602,0.0011251,0.001059945,0.00007116176,0.00002676605,0.00008802612,0.000940324,0.00001719292,0.00131112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001225399,"threshold_uncertainty_score":0.003782868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03427321049620357,"score_gpt":0.3748195694005811,"score_spread":0.3405463589043776,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}