{"id":"W2110962636","doi":"10.1186/1476-4598-9-271","title":"The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Canadian Association of Gastroenterology; Crohn's and Colitis Foundation of Canada","keywords":"Biology; KRAS; Carcinogenesis; Cancer research; MAPK/ERK pathway; Kinase; MEK inhibitor; Colorectal cancer; Molecular biology; Cancer; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007219325,0.0004221477,0.0002147716,0.0002622283,0.0001537662,0.0003054919,0.0001331145,0.0002040928,0.001315388],"category_scores_gemma":[0.0001111057,0.00008411531,0.0002996881,0.0001473091,0.000151287,0.0001276902,0.0001182995,0.0003581139,0.0005496647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002417608,"about_ca_system_score_gemma":0.0001449797,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000330239,"about_ca_topic_score_gemma":0.0004214332,"domain_scores_codex":[0.9999372,0.000007378823,0.000004935083,0.00001717673,0.00002157182,0.0000118391],"domain_scores_gemma":[0.9999259,0.000009302958,0.00002840411,0.000005534232,0.00001179763,0.00001909291],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004301308,0.00002963616,0.001146811,0.0001347463,0.00001716253,0.0008060205,0.00001492898,0.00009744801,0.9925174,0.0001008522,0.0002023376,0.004502551],"study_design_scores_gemma":[0.00005198877,0.0004083173,0.02953536,0.00001866768,0.00008925869,0.006458511,0.00004931411,0.001330614,0.9479275,0.0001747157,0.01394199,0.00001364788],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9718066,0.01476608,0.006701041,0.0004520201,0.0001485757,0.00006091997,0.001669054,0.0003643419,0.004031379],"genre_scores_gemma":[0.9883639,0.003587913,0.002502645,0.00008575268,0.00006638218,0.00002391329,0.001564845,0.00002830392,0.003776396],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001315388,"threshold_uncertainty_score":0.004400373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007997924231554338,"score_gpt":0.2428362163992162,"score_spread":0.2348382921676619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}