{"id":"W2110962636","doi":"10.1186/1476-4598-9-271","title":"The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis","year":2010,"lang":"en","type":"article","venue":"Molecular Cancer","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Université de Sherbrooke","funders":"Canadian Institutes of Health Research; Canadian Association of Gastroenterology; Crohn's and Colitis Foundation of Canada","keywords":"Biology; KRAS; Carcinogenesis; Cancer research; MAPK/ERK pathway; Kinase; MEK inhibitor; Colorectal cancer; Molecular biology; Cancer; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000207264,0.0001769197,0.0001765223,0.00004096809,0.0000937103,0.00001917934,0.0002408902,0.0001424265,0.00004749361],"category_scores_gemma":[0.00005219263,0.0001449328,0.0001078567,0.0001364694,0.0001002917,0.000003955559,0.0001161257,0.0001658721,0.000001569065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001715865,"about_ca_system_score_gemma":0.0001924641,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002921949,"about_ca_topic_score_gemma":0.0007136443,"domain_scores_codex":[0.9989161,0.00003572372,0.0002801837,0.0003262567,0.0001619648,0.0002797271],"domain_scores_gemma":[0.9993379,0.000006313629,0.0001224828,0.0003417903,0.0001100161,0.00008153314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009320876,0.00007118644,0.007342766,0.00003344165,0.00003698208,0.000009543815,0.00006498722,0.00006020684,0.9917982,0.0001272373,0.000198107,0.0001640834],"study_design_scores_gemma":[0.0006689635,0.0001626137,0.002109328,0.00002151004,0.00001182156,0.000003083831,0.0000332601,0.00008748283,0.9860406,0.00007253989,0.01060485,0.0001839461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979855,0.0005464487,0.0004023754,0.0001666301,0.0002492099,0.0004210798,0.00006117223,0.000008697,0.0001588212],"genre_scores_gemma":[0.9983138,0.00002152285,0.0007608415,0.000206347,0.0002205002,0.0002485096,0.00004354076,0.00003304385,0.0001519106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01040675,"threshold_uncertainty_score":0.5910187,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007997924231554338,"score_gpt":0.2428362163992162,"score_spread":0.2348382921676619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}