{"id":"W2110964550","doi":"10.1186/1472-6750-8-23","title":"Effects of size and topology of DNA molecules on intracellular delivery with non-viral gene carriers","year":2008,"lang":"en","type":"article","venue":"BMC Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"DNA; Biology; Gene delivery; Molecular biology; Lipofectamine; In vitro recombination; Plasmid; Exogenous DNA; Transfection; Reporter gene; Gene; Biophysics; Gene expression; Biochemistry; Recombinant DNA; Molecular cloning; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004395234,0.0001693585,0.0002780044,0.0000957527,0.00003935619,0.000001544318,0.0001945542,0.0004955617,0.000003993753],"category_scores_gemma":[0.00007988461,0.0001453111,0.00005959518,0.00008348357,0.0007885732,0.000002577967,0.0001113999,0.0001190407,0.000002082055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006641542,"about_ca_system_score_gemma":0.00007635084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004774407,"about_ca_topic_score_gemma":0.00003052833,"domain_scores_codex":[0.9991394,0.00003853668,0.0001985173,0.0003354855,0.00007352843,0.000214509],"domain_scores_gemma":[0.9994078,0.00003851936,0.0001220659,0.0003301714,0.00006084355,0.00004055127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003924221,0.00006467518,0.002976397,0.00006009525,0.00006620587,0.00003160883,0.00003584459,0.00002755309,0.9956437,0.0001339924,0.00007250925,0.0004949913],"study_design_scores_gemma":[0.0007902239,0.002924807,0.005164985,0.00002093584,0.00003004299,0.0001025901,0.00006097977,0.00002475664,0.9905116,0.00004090059,0.0001808432,0.0001473224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951757,0.001286683,0.003144511,0.00006989302,0.0000595458,0.0001721606,0.00001037775,0.00001268686,0.00006841026],"genre_scores_gemma":[0.9947925,0.001059674,0.003910478,0.00009041472,0.00002800674,0.00001206287,0.00001006083,0.00001566421,0.0000812006],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005132092,"threshold_uncertainty_score":0.5925615,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004304663757882468,"score_gpt":0.1901670089209096,"score_spread":0.1858623451630272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}