{"id":"W2110964550","doi":"10.1186/1472-6750-8-23","title":"Effects of size and topology of DNA molecules on intracellular delivery with non-viral gene carriers","year":2008,"lang":"en","type":"article","venue":"BMC Biotechnology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"DNA; Biology; Gene delivery; Molecular biology; Lipofectamine; In vitro recombination; Plasmid; Exogenous DNA; Transfection; Reporter gene; Gene; Biophysics; Gene expression; Biochemistry; Recombinant DNA; Molecular cloning; Vector (molecular biology)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005990053,0.0003492956,0.0001449487,0.0001925485,0.0001100959,0.0003662184,0.000249854,0.0003373538,0.0008472585],"category_scores_gemma":[0.001526465,0.0001559865,0.0001672703,0.0001177509,0.000345725,0.0004530308,0.0001825883,0.0002811897,0.0002048631],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002776035,"about_ca_system_score_gemma":0.0001672174,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003006866,"about_ca_topic_score_gemma":0.0002551426,"domain_scores_codex":[0.99965,0.0001174515,0.00002840841,0.00006592321,0.0001024145,0.00003583796],"domain_scores_gemma":[0.9985518,0.0008902837,0.0002835871,0.0000437403,0.0001275347,0.0001031976],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001770839,0.00003342358,0.0004799966,0.00008056676,0.000009641148,0.00007932601,0.00004081356,0.0004115611,0.996752,0.00007567075,0.00001517107,0.001844837],"study_design_scores_gemma":[0.00001417626,0.0004973146,0.001169525,0.000006202814,0.00001999728,0.0001252605,0.00002037443,0.001297213,0.996352,0.0000292294,0.0004627033,0.000006079605],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995006,0.001439944,0.002761739,0.00004825467,0.00001738863,0.00003581833,0.00004076519,0.0000262234,0.0006237425],"genre_scores_gemma":[0.9967557,0.0006841414,0.002050207,0.00003316739,0.000007702884,0.00003432424,0.00006804883,0.00002181053,0.0003449491],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008472585,"threshold_uncertainty_score":0.003167927,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004304663757882468,"score_gpt":0.1901670089209096,"score_spread":0.1858623451630272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}