{"id":"W2110986932","doi":"10.1093/hmg/dds192","title":"Epigenetic markers of prostate cancer in plasma circulating DNA","year":2012,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Prostate cancer; Biology; Biomarker; Epigenetics; Epigenomics; DNA methylation; Prostate; Cancer; Biomarker discovery; Disease; Oncology; Computational biology; Bioinformatics; Cancer research; Internal medicine; Gene; Genetics; Proteomics; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003317885,0.0002146488,0.0002798031,0.0006983881,0.0001559462,0.0004635959,0.0001871817,0.0003110245,0.001529796],"category_scores_gemma":[0.001234472,0.000158326,0.0001576144,0.0008261698,0.0001688296,0.0001414499,0.0002324859,0.0004377156,0.0002415124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002236013,"about_ca_system_score_gemma":0.0001909357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007446745,"about_ca_topic_score_gemma":0.0008470559,"domain_scores_codex":[0.9997349,0.00004595046,0.00001307352,0.0001014212,0.00008272488,0.00002183171],"domain_scores_gemma":[0.9995663,0.0001408704,0.0001380318,0.00004040685,0.0000598326,0.00005464784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001012211,0.0001500585,0.3653305,0.0002255855,0.0002124214,0.0003913698,0.0002114978,0.00168642,0.5769106,0.0004052578,0.0009600176,0.05250405],"study_design_scores_gemma":[0.00004520639,0.0007819599,0.8737536,0.00002397843,0.0001853663,0.00189175,0.00009513892,0.008751232,0.1097509,0.001006824,0.003681012,0.0000329469],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9847249,0.002746732,0.008464908,0.0001684462,0.00003720232,0.00003846358,0.001786994,0.0003362782,0.001696004],"genre_scores_gemma":[0.990902,0.0004371174,0.006700198,0.00008624076,0.00003975708,0.00003406583,0.001157466,0.00001406213,0.0006289741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001529796,"threshold_uncertainty_score":0.005117655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450830414403049,"score_gpt":0.2832701439944216,"score_spread":0.2687618398503911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}