{"id":"W2110986932","doi":"10.1093/hmg/dds192","title":"Epigenetic markers of prostate cancer in plasma circulating DNA","year":2012,"lang":"en","type":"article","venue":"Human Molecular Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Institute for Cancer Research; University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"Prostate cancer; Biology; Biomarker; Epigenetics; Epigenomics; DNA methylation; Prostate; Cancer; Biomarker discovery; Disease; Oncology; Computational biology; Bioinformatics; Cancer research; Internal medicine; Gene; Genetics; Proteomics; Medicine; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003380053,0.0002268412,0.0002189825,0.0001191429,0.00005850009,0.00001514303,0.0001922542,0.0001864972,0.00004329981],"category_scores_gemma":[0.00004549413,0.0002568788,0.0001099032,0.0001796991,0.00009730906,0.000004092428,0.0001280243,0.0001058448,0.000003796873],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002939495,"about_ca_system_score_gemma":0.00006312819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004279982,"about_ca_topic_score_gemma":0.00007506529,"domain_scores_codex":[0.9983326,0.0001339262,0.0004747205,0.0003278546,0.0002408162,0.0004900869],"domain_scores_gemma":[0.9991208,0.00001077042,0.0001960149,0.0004404068,0.00009592524,0.0001360905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002208245,0.00007407414,0.1347475,0.000039824,0.00003636662,0.000002673731,0.0001585797,0.004034153,0.8565204,0.00007345346,0.0000104181,0.004280499],"study_design_scores_gemma":[0.0005583683,0.0001771025,0.1916636,0.00003452639,0.00003137254,0.000001947724,0.00005774647,0.000249811,0.8056581,0.0001940821,0.001087028,0.0002863142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855071,0.01216068,0.0006348207,0.00001695284,0.0001505678,0.0003303396,0.00001893803,0.000007681121,0.00117287],"genre_scores_gemma":[0.9976061,0.000757025,0.001207438,0.00003798842,0.0001236245,0.00004342692,0.00006709455,0.00005970242,0.00009761193],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05691606,"threshold_uncertainty_score":0.9999883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01450830414403049,"score_gpt":0.2832701439944216,"score_spread":0.2687618398503911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}