{"id":"W2110987418","doi":"10.4161/cc.6.5.3923","title":"XRCC3 Depletion Induces Spontaneous DNA Breaks and p53-Dependent Cell Death","year":2007,"lang":"en","type":"article","venue":"Cell Cycle","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"XRCC3; Biology; Cell cycle; DNA repair; Homologous recombination; DNA damage; Cell biology; DNA replication; Gene knockdown; Programmed cell death; DNA; Molecular biology; Cell; Apoptosis; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002471965,0.0001513936,0.0001065881,0.00003708355,0.00007529528,0.00002639595,0.0001294969,0.000196164,0.00003337806],"category_scores_gemma":[0.0000126287,0.0001545022,0.00004951763,0.00003649783,0.0000269813,0.000003651518,0.0001154103,0.00008856872,0.00003859685],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001969174,"about_ca_system_score_gemma":0.00002528195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005020355,"about_ca_topic_score_gemma":0.00008514098,"domain_scores_codex":[0.9990138,0.00002847263,0.0001610586,0.0003686461,0.0001352169,0.0002927494],"domain_scores_gemma":[0.9994764,0.00001253938,0.0000641404,0.0002838553,0.00003398319,0.0001290849],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005361592,0.00007541361,0.0003736467,0.0000173316,0.000006850676,0.0001364848,0.00004777088,0.000009550253,0.9970671,0.00002819832,0.0001035046,0.002080513],"study_design_scores_gemma":[0.0004235916,0.0002136294,0.001971462,0.000004490741,0.00001738936,0.0002444109,0.0001164254,0.00002870968,0.9928004,0.0001474484,0.003833532,0.0001985104],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829209,0.0005817551,0.001179638,0.00001612051,0.0001711017,0.0001518878,0.000006700352,0.000032317,0.01493955],"genre_scores_gemma":[0.996196,0.0001078534,0.001093218,0.0001707654,0.000161283,0.000005104253,0.00004180642,0.00003027141,0.002193708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01327506,"threshold_uncertainty_score":0.6300417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005958085060246633,"score_gpt":0.2145717552644477,"score_spread":0.2086136702042011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}