{"id":"W2110987418","doi":"10.4161/cc.6.5.3923","title":"XRCC3 Depletion Induces Spontaneous DNA Breaks and p53-Dependent Cell Death","year":2007,"lang":"en","type":"article","venue":"Cell Cycle","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"XRCC3; Biology; Cell cycle; DNA repair; Homologous recombination; DNA damage; Cell biology; DNA replication; Gene knockdown; Programmed cell death; DNA; Molecular biology; Cell; Apoptosis; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001402332,0.0004008157,0.0003912135,0.0002397614,0.0001480389,0.0002312316,0.0001929214,0.0003789029,0.001842424],"category_scores_gemma":[0.0001253587,0.0001572393,0.0003173091,0.0001786205,0.0002288276,0.0001654966,0.0002180389,0.0005064537,0.0005588532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003763822,"about_ca_system_score_gemma":0.0001946208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006459589,"about_ca_topic_score_gemma":0.001344432,"domain_scores_codex":[0.9997775,0.00003154303,0.0000257536,0.00005327027,0.00005805281,0.00005387282],"domain_scores_gemma":[0.9998201,0.00004101179,0.0000511021,0.00003637642,0.00001809122,0.00003336881],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007031226,0.0000196601,0.0001165565,0.00002680788,0.00000800903,0.00006508139,0.000008729945,0.00002767843,0.9989503,0.00004717667,0.00005936792,0.0006003752],"study_design_scores_gemma":[0.00001286406,0.0002585148,0.004096223,0.000003900841,0.000006692178,0.0002631306,0.00001103586,0.0002664246,0.9938077,0.0000294984,0.001241272,0.000002710644],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889784,0.00433003,0.003078629,0.0001353749,0.00004087043,0.0000627414,0.001238437,0.0002158156,0.001919528],"genre_scores_gemma":[0.9920714,0.001384538,0.001508696,0.00008370226,0.00001211368,0.00008276127,0.001672474,0.00004469151,0.003139601],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001842424,"threshold_uncertainty_score":0.006163597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005958085060246633,"score_gpt":0.2145717552644477,"score_spread":0.2086136702042011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}