{"id":"W2111014532","doi":"10.1124/mol.110.065896","title":"Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors","year":2010,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Mesothelioma Applied Research Foundation; National Eye Institute; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Barbara Ann Karmanos Cancer Institute","keywords":"Chinese hamster ovary cell; Antifolate; Biochemistry; Chemistry; Pyrimidine; Purine; Purine metabolism; Stereochemistry; Biology; Methotrexate; Antimetabolite; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001471676,0.0002375558,0.0004119543,0.0001692467,0.0001972911,0.0004159529,0.0003475571,0.0005871553,0.0009554552],"category_scores_gemma":[0.0001112874,0.0001862254,0.000175825,0.0001579029,0.000176281,0.0003649013,0.0001647684,0.0004324996,0.0002942785],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005808824,"about_ca_system_score_gemma":0.0002925466,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00162491,"about_ca_topic_score_gemma":0.002497742,"domain_scores_codex":[0.9999245,0.00001830379,0.000004436086,0.00001481316,0.00001587448,0.00002207092],"domain_scores_gemma":[0.9999669,0.000008270316,0.000009861883,0.00000283099,0.00000530021,0.000006950928],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003200121,0.00004126942,0.00007015748,0.00009112891,0.00001264287,0.0001027862,0.0000310016,0.0004092053,0.9902855,0.0005275895,0.0002027822,0.007905923],"study_design_scores_gemma":[0.00007750907,0.0005813668,0.0004567868,0.000005465885,0.00003090121,0.0003467253,0.00001582525,0.003188967,0.9903792,0.00004906071,0.004858276,0.000009797097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.978218,0.009146729,0.008960009,0.0005286607,0.00008752513,0.00007852109,0.0002323913,0.0001388756,0.00260922],"genre_scores_gemma":[0.9908421,0.002748939,0.003992986,0.00005552313,0.00001854868,0.00002364322,0.00009725163,0.00001761739,0.002203423],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00162491,"threshold_uncertainty_score":0.004214585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115007996246826,"score_gpt":0.3115547720023202,"score_spread":0.3004046920398519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}