{"id":"W2111014532","doi":"10.1124/mol.110.065896","title":"Targeting the Proton-Coupled Folate Transporter for Selective Delivery of 6-Substituted Pyrrolo[2,3-d]Pyrimidine Antifolate Inhibitors of De Novo Purine Biosynthesis in the Chemotherapy of Solid Tumors","year":2010,"lang":"en","type":"article","venue":"Molecular Pharmacology","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Mesothelioma Applied Research Foundation; National Eye Institute; National Cancer Institute; National Institutes of Health; Canadian Institutes of Health Research; Barbara Ann Karmanos Cancer Institute","keywords":"Chinese hamster ovary cell; Antifolate; Biochemistry; Chemistry; Pyrimidine; Purine; Purine metabolism; Stereochemistry; Biology; Methotrexate; Antimetabolite; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001261013,0.0001988688,0.0005665714,0.0002754019,0.00005378042,0.000003242736,0.0003227083,0.0001618265,0.0000778578],"category_scores_gemma":[0.0001026355,0.0001258295,0.0002243678,0.0005774744,0.0003618125,0.00004798365,0.00002769904,0.0004805199,7.398667e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002698504,"about_ca_system_score_gemma":0.0002516628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000149358,"about_ca_topic_score_gemma":0.00002307696,"domain_scores_codex":[0.9982477,0.0001517383,0.0006276371,0.0002634147,0.0002693065,0.0004401657],"domain_scores_gemma":[0.9988426,0.0002618514,0.0002571326,0.0002372887,0.0003428078,0.0000583371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002175565,0.0006026498,0.003967642,0.0003579464,0.0003717806,0.00008613656,0.001006782,0.0000842327,0.9906749,0.00001724346,0.00006943856,0.0005857319],"study_design_scores_gemma":[0.003703711,0.0006570321,0.006193569,0.00004628678,0.0002123843,0.00004438838,0.00009595467,0.005754081,0.982974,0.00004930852,0.0001630734,0.0001061908],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99524,0.0001680421,0.0002644359,0.001269143,0.00008212327,0.002897261,0.00003177648,0.00001248049,0.00003469919],"genre_scores_gemma":[0.9987287,0.0001238666,0.0004180529,0.0003320944,0.00006827572,0.0002678462,0.00001677056,0.00003593741,0.000008460372],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007700831,"threshold_uncertainty_score":0.5131179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01115007996246826,"score_gpt":0.3115547720023202,"score_spread":0.3004046920398519,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}