{"id":"W2111058339","doi":"10.1021/jo500927x","title":"A Systematic Study of the Effects of Relative Configuration, Protecting Group, and Enolate Type on the Diastereoselectivities of Aldol Reactions of a Chiral Ethyl Ketone with 2-Methylpropanal","year":2014,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Aldol reaction; Diastereomer; Chemistry; Transmetalation; Enol; Ketone; Adduct; Stereoselectivity; Stereochemistry; Aldol condensation; Medicinal chemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005856669,0.0007482957,0.0002719269,0.0003545651,0.0001940408,0.0002891052,0.0002687123,0.0001790034,0.0009831453],"category_scores_gemma":[0.0006354186,0.0002396535,0.0002180927,0.0004271143,0.0002654977,0.0003603294,0.0002872956,0.000402952,0.000348899],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001518225,"about_ca_system_score_gemma":0.0003058929,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005011564,"about_ca_topic_score_gemma":0.001161285,"domain_scores_codex":[0.9996766,0.00008458823,0.0000504979,0.00006260481,0.00005427351,0.00007151065],"domain_scores_gemma":[0.9994765,0.0001838202,0.0001105407,0.00008284859,0.00008221883,0.00006411153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003406833,0.00007028591,0.00090461,0.0001205479,0.00002711149,0.0001152503,0.00008327473,0.0002121579,0.9915034,0.00006268216,0.00004415801,0.006515938],"study_design_scores_gemma":[0.000009854762,0.0003789547,0.002677403,0.000007614567,0.00003530189,0.00009398445,0.00003124271,0.000162435,0.9955712,0.00001227273,0.001010846,0.000008952349],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993073,0.001879303,0.001840458,0.00003896904,0.00001544869,0.00005075115,0.0002461379,0.00005357216,0.002802431],"genre_scores_gemma":[0.9933105,0.002873959,0.002302714,0.00003820403,0.00001524795,0.00003505746,0.0003103551,0.00004888309,0.001065096],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009831453,"threshold_uncertainty_score":0.003288984,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006010366842109754,"score_gpt":0.1933209234681159,"score_spread":0.1873105566260062,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}