{"id":"W2111066657","doi":"10.1152/ajpheart.00649.2006","title":"Erythropoietin promotes survival of primary human endothelial cells through PI3K-dependent, NF-κB-independent upregulation of Bcl-x<sub>L</sub>","year":2007,"lang":"en","type":"article","venue":"American Journal of Physiology-Heart and Circulatory Physiology","topic":"Erythropoietin and Anemia Treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Michael Smith Health Research BC; Canadian Institutes of Health Research; Heart and Stroke Foundation of British Columbia and Yukon; Heart and Stroke Foundation of Canada","keywords":"Erythropoietin; PI3K/AKT/mTOR pathway; MAPK/ERK pathway; Downregulation and upregulation; Cell biology; Kinase; Apoptosis; Signal transduction; Protein kinase A; Cancer research; Chemistry; Biology; Endocrinology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006623339,0.0003896977,0.001729831,0.0002104755,0.0001292065,0.000004692126,0.0001774135,0.0002082506,0.00006927962],"category_scores_gemma":[0.00003180057,0.0003216573,0.0004619636,0.0002315616,0.001879662,0.0001361554,0.00009288553,0.0004990388,0.000006867684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001167578,"about_ca_system_score_gemma":0.0002251986,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007405548,"about_ca_topic_score_gemma":0.000007757535,"domain_scores_codex":[0.9969777,0.0003187601,0.001227972,0.0004960956,0.0004614507,0.0005179768],"domain_scores_gemma":[0.9972423,0.0002647596,0.001452129,0.0004508173,0.0003801237,0.0002098457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008349871,0.000958534,0.005303135,0.0002434392,0.0004398063,0.000005436962,0.0006008287,0.00003267713,0.9902161,0.0001746008,0.0001214924,0.001068929],"study_design_scores_gemma":[0.002137448,0.003061101,0.4725315,0.0001263837,0.0002142168,0.0001729094,0.000754361,0.000003899695,0.5199386,0.0007820473,0.00009710378,0.0001803396],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983402,0.0005063024,0.00002249034,0.000156797,0.0004140063,0.0003201096,0.00002217092,0.00002166594,0.0001962102],"genre_scores_gemma":[0.9982378,0.0002583296,0.0006276109,0.0002323269,0.0005467611,0.000003733024,0.00002961922,0.0000469033,0.00001691448],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4702775,"threshold_uncertainty_score":0.9999235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01432404115442136,"score_gpt":0.2616965276823843,"score_spread":0.2473724865279629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}