{"id":"W2111091913","doi":"10.1074/jbc.m301364200","title":"Activation of the p70 S6 Kinase and Phosphorylation of the 4E-BP1 Repressor of mRNA Translation by Type I Interferons","year":2003,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; McGill University; University Health Network","funders":"","keywords":"P70-S6 Kinase 1; EIF4E; Protein kinase R; Cell biology; Biology; Phosphorylation; Kinase; MAP2K7; ASK1; Mitogen-activated protein kinase kinase; PI3K/AKT/mTOR pathway; MAP kinase kinase kinase; Protein kinase A; Cyclin-dependent kinase 2; Chemistry; Signal transduction; Translation (biology); Biochemistry; Messenger RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002520191,0.00007946298,0.0001510894,0.000006460151,0.00002369072,0.000002974955,0.0001657417,0.0001815921,0.00003184235],"category_scores_gemma":[0.0003755027,0.00004434124,0.000109744,0.00008242296,0.000171955,0.000005318399,0.00002386061,0.0001360227,3.481911e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001386247,"about_ca_system_score_gemma":0.00005315711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000221497,"about_ca_topic_score_gemma":2.210024e-7,"domain_scores_codex":[0.9992718,0.00007215093,0.0003592596,0.0001057603,0.0001214322,0.00006959177],"domain_scores_gemma":[0.9990142,0.00004432742,0.000569346,0.0001741288,0.0001729477,0.00002507225],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001979425,0.00005483321,0.006425337,0.0000294505,0.00003572682,7.604727e-8,0.0000259548,0.00006876091,0.9924228,0.00000568858,0.00021374,0.0005196979],"study_design_scores_gemma":[0.0003309953,0.0001700024,0.003131438,0.00006681034,0.00002200032,0.000008934568,0.00003443499,0.00001120369,0.9947758,0.000110884,0.001289491,0.00004797459],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977374,0.001459244,0.0002580039,0.0001236088,0.00007402778,0.0000581181,0.00001354629,8.94155e-7,0.0002751515],"genre_scores_gemma":[0.99952,0.0001945531,0.0001603348,0.00003118332,0.00004161521,9.04553e-7,0.000004826049,0.000004476009,0.00004210848],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003293899,"threshold_uncertainty_score":0.1808183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02207228489763568,"score_gpt":0.2568869163716091,"score_spread":0.2348146314739734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}