{"id":"W2111108128","doi":"10.1128/jvi.78.6.2666-2673.2004","title":"Neutralizing Antibodies and CD8 <sup>+</sup> T Lymphocytes both Contribute to Immunity to Adenovirus Serotype 5 Vaccine Vectors","year":2004,"lang":"en","type":"article","venue":"Journal of Virology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":172,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health","keywords":"Immunogenicity; Virology; Immunity; Biology; Immune system; Humoral immunity; Antibody; Cellular immunity; Immunology; Adoptive cell transfer; CD8; Adenoviridae; Neutralizing antibody; Immunization; T cell; Recombinant DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004066677,0.0005838166,0.0002014643,0.0002134915,0.0000899095,0.0003350695,0.0001548025,0.0003637948,0.001401088],"category_scores_gemma":[0.0002696567,0.0001273262,0.0001823078,0.00007032163,0.0002974941,0.0002220549,0.0001819466,0.0005326658,0.0003939355],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001744899,"about_ca_system_score_gemma":0.0001889788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001221914,"about_ca_topic_score_gemma":0.0001885715,"domain_scores_codex":[0.9997992,0.00005727138,0.00001971874,0.00003164283,0.0000437987,0.00004848027],"domain_scores_gemma":[0.9997812,0.00007226538,0.0000557821,0.00002396081,0.00002930579,0.00003755105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000282012,0.000101633,0.002708786,0.0001284668,0.000014391,0.00007568557,0.00002798596,0.0001860559,0.9662939,0.0007235573,0.00008784647,0.02936977],"study_design_scores_gemma":[0.00008280617,0.002000309,0.01236015,0.00003795198,0.00008093427,0.001257242,0.00006351653,0.001762985,0.9711188,0.000825687,0.01040064,0.000009079404],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9690654,0.00817937,0.01601315,0.0003213125,0.0001265892,0.00008955997,0.00005825667,0.0001497209,0.005996571],"genre_scores_gemma":[0.9870984,0.002694477,0.006977474,0.0001838307,0.00007172018,0.00005298431,0.0001169604,0.00001156341,0.002792654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001401088,"threshold_uncertainty_score":0.00468713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01458929000122461,"score_gpt":0.299422670520516,"score_spread":0.2848333805192914,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}