{"id":"W2111113717","doi":"10.4049/jimmunol.1301776","title":"AID and Caspase 8 Shape the Germinal Center Response through Apoptosis","year":2013,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Germinal center; Somatic hypermutation; Apoptosis; Biology; Molecular biology; CD40; Affinity maturation; Immunoglobulin class switching; B cell; Cell biology; Immune system; Antibody; Immunology; Genetics; In vitro; Cytotoxic T cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825428,0.0003286921,0.0002529045,0.0003016689,0.0001767844,0.000625069,0.0002338309,0.0006055358,0.001828786],"category_scores_gemma":[0.0002373045,0.0002288158,0.0002070977,0.0001026503,0.0003908001,0.0004386241,0.0004763303,0.0008061312,0.0009583109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003620802,"about_ca_system_score_gemma":0.0001596424,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000134941,"about_ca_topic_score_gemma":0.0001956378,"domain_scores_codex":[0.9997441,0.00004942431,0.0000161254,0.00004205137,0.00006873636,0.0000796036],"domain_scores_gemma":[0.9997787,0.00003045485,0.00005263988,0.00002149688,0.00003826175,0.00007840238],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005207752,0.00003439432,0.0007292122,0.00007383059,0.000006798684,0.0001213096,0.00003736139,0.0001614118,0.992772,0.0007654639,0.0001751141,0.004602377],"study_design_scores_gemma":[0.0001702306,0.0007103245,0.01176626,0.00002402506,0.00002956278,0.001038189,0.0001643425,0.002673882,0.9722315,0.001132888,0.01004504,0.00001375529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849759,0.006128012,0.00384142,0.000329864,0.00009089932,0.00003365903,0.0001842753,0.0001685379,0.004247483],"genre_scores_gemma":[0.9944212,0.0008808305,0.001917973,0.00009484534,0.00002359993,0.00001915531,0.0001098798,0.00001684746,0.00251573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001828786,"threshold_uncertainty_score":0.00611794,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01336096188455447,"score_gpt":0.2321712937289336,"score_spread":0.2188103318443791,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}